This Project Grant award, valued at $128,286, was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of the project is to uncover the underlying cellular mechanisms that contribute to the effects of free fatty acid-induced lipotoxicity in kidney tubular epithelial cells and the development of chronic kidney disease (CKD). The research will be conducted at The...
This Project Grant award of $2,202,378 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the protective role of the transcription factor KLF2 in diabetic kidney disease (DKD). The key research objectives are to: 1) determine how KLF2 is regulated under diabetic conditions, 2) elucidate how KLF2 protects against glomerular endothelial cell...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This federal Project Grant award of $579,097 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to The University of Texas MD Anderson Cancer Center. The funding supports research focused on understanding the role of mitochondrial electron transport chain (ETC) dysfunction in the development and progression of diabetic kidney disease (DKD). The research aims to identify novel regulatory...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $199,999 to the University of Florida to develop innovative artificial intelligence (AI)-based methods to support the discovery of potent, orally available small-molecule heparanase inhibitors. The goal is to evaluate these novel heparanase inhibitors in murine models as a...
This federal Project Grant award of $830,500.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to investigate the role of glycosphingolipids in the development and progression of kidney disease in obesity and diabetes. The award, effective January 20, 2025 through November 30, 2028, will fund studies conducted by Georgetown University to test hypotheses that...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will provide $596,345.00 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility in diabetes. The goal is to investigate how impaired...
This $1,145,486 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop novel peripherally acting CB1 neutral antagonists for the treatment of diabetic kidney disease (DKD). The awardee, Makscientific LLC, a for-profit R&D company, will design and synthesize new analogs of compound AM6588 to improve potency, selectivity, oral...
This Project Grant award, valued at $400,000 and awarded on September 5, 2024, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research conducted by the University of Mississippi Medical Center to investigate the role of insulin resistance in the development of renal disease during prepubertal childhood obesity, in the absence of diabetes....
This federal Project Grant award for $892,433.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research aimed at understanding the role of eicosanoids (bioactive lipid molecules) in the development of chronic kidney disease (CKD) and associated cardiovascular risk. The research project, led by the principal investigator at Cedars-Sinai Medical Center,...