The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $199,990 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Ohio State University. The grant supports research to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The research aims to determine how CTBP2 activation and regulation contribute to renal epithelial cell dysfunction and...
The federal Project Grant award F31DK136312, totaling $128,286.00, was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to uncover the underlying cellular mechanisms that contribute to the effects of free fatty acid-induced lipotoxicity in kidney tubular epithelial cells and the development of chronic kidney disease (CKD). The research will be...
This federal Project Grant award of $253,500.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to develop state-of-the-art approaches to selectively target and degrade a mutant variant of the KLF1 transcription factor, which can lead to congenital dyserythropoietic anemia (CDA) when mutated. The research, summarized in two main aims, will...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $200,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Washington University in St. Louis. The grant's objective is to delineate the molecular mechanism regulating autophagy in autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by uromodulin (UMOD) mutations. The research aims to develop new therapeutic strategies for ADTKD...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Vanderbilt University a 2-year, $356,625 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The objective is to develop a multi-tissue 13C metabolic flux analysis (MFA) platform to simultaneously assess kidney metabolism and its relationship with liver and heart metabolism in live animal models. Key products and services to be delivered include: 1)...
This federal Project Grant award for $273,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to investigate the role of phospholipid homeostasis in cellular and organismal physiology, with a focus on understanding the function of the choline transporter protein FLVCR1 and its impact on mitochondrial function and cellular stress...
This $746,198 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the relationship between per- and polyfluoroalkyl substances (PFAS) exposure and diabetic kidney disease (DKD) in youth with type 2 diabetes. The award will leverage data from two existing NIDDK-funded longitudinal cohort studies to assess how PFAS exposure...
This $200,000 Project Grant awarded on September 17, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA Program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research supports a case-cohort study to identify novel risk factors for end-stage kidney disease (ESKD) among living kidney donors. The study aims to improve the counseling and selection of living kidney donors by developing tailored risk prediction tools based on donor...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $117,000.00 to the Regents of the University of Michigan to conduct a systems biology research project. The project aims to identify gene regulatory networks related to the hypoxia inducible factor-1a (HIF1a) in the kidney cortex and medulla, and investigate how these networks...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) is providing $645,599 to the University of Pittsburgh to conduct research on using dicarboxylic acid (DCA) therapy to prevent and treat acute kidney injury (AKI). The research aims to understand how DCA can metabolically protect the kidney against injury and limit the progression to chronic kidney disease. This...