Project Grant R44DK139888

Award Date 9/1/24
Completion Date 6/30/25
Dollars Obligated $1.1M
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Burlington, MA 01803, USA
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This $675,480 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to develop a novel therapeutic compound for treating chronic kidney disease (CKD). The awardee, Fibrotherapeutics Inc., is conducting preclinical studies to evaluate the efficacy, safety, and therapeutic index of a modified, water-soluble, orally-active peptide derived...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Biotherapeutics, Inc. a $359,625 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports the development of next-generation, once-daily oral therapeutic candidates for the treatment of pre-diabetes and type 2 diabetes. Key research objectives include evaluating the therapeutic efficacy of the lead drug candidate on lipid metabolism, insulin...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $349,325 Project Grant under CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research to Regennova, Inc., a small disadvantaged business in Durham, North Carolina. The grant supports the development of an orally-available, effective, and well-tolerated drug to treat autosomal dominant polycystic kidney disease (ADPKD), which affects over 350,000 Americans. The project aims to create and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $579,097 Project Grant to The University of Texas MD Anderson Cancer Center. The grant, with a period of performance from July 1, 2025 to March 31, 2030, will fund research to identify and dissect the molecular mechanisms of regulators affecting mitochondrial electron transport chain (ETC) dysfunction in diabetic...
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The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,145,486 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Makscientific LLC, a for-profit research and development company located in Burlington, MA. The grant supports the development of novel peripherally acting CB1 neutral antagonists for treating diabetic kidney disease (DKD). The project aims to design and synthesize improved analogs of compound AM6588 to enhance potency, selectivity, oral bioavailability, and metabolic stability, while reducing brain permeability. Key research activities include evaluating the analogs' absorption, distribution, metabolism, and excretion (ADME) profiles, selecting an advanced lead candidate, and conducting efficacy testing in validated DKD animal models to prepare for Investigational New Drug (IND) filing. This work builds on Makscientific's prior research demonstrating that CB1 antagonists can positively impact metabolic and renal function in diabetic conditions.

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