Project Grant R01DK143239

Award Date 7/1/25
Completion Date 4/30/30
Dollars Obligated $646K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
This federal Project Grant award of $2,175,896.00 was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to the Icahn School of Medicine at Mount Sinai. The grant supports advanced biomedical research aimed at transforming healthcare for military service members, veterans, and the broader public, with a specific focus on understanding the metabolites, metabolic pathways, and risk of Crohn's disease. The project will be conducted at the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a 5-year research program focused on defining novel neuro-immune pathways that regulate gut physiology. The $168,296 award to Weill Medical College of Cornell University aims to investigate the role of enzymes in group 3 innate lymphoid cells (ILC3s) and their impact on inflammatory bowel disease (IBD) and...
This federal Project Grant award of $151,643, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on developing and evaluating Proteolysis Targeting Chimeras (PROTACs) to stabilize hypoxia-inducible factors (HIFs) as a potential therapeutic approach for inflammatory bowel disease (IBD). The principal investigator, Dr. Ornelas Sanchez, and his...
This Project Grant award of $1,560,024 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 supports research on the intracellular trafficking and signaling of the metabolite heme in myeloid cells. The primary awardee, Scripps Research Institute, will leverage mouse models, chemical tools, and new mouse mutants to reveal a molecular pathway for how heme signaling regulates the differentiation and function of macrophages under normal and disease...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $859,704 to support research on how the endoplasmic reticulum (ER) protein AGR2 regulates host-microbe interactions and inflammatory responses in Crohn's disease. The research aims to elucidate the cellular and molecular mechanisms by which AGR2 deficiency leads to ER stress, bacterial dysbiosis, and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,007,304 supports research to investigate how genetic variants associated with inflammatory bowel diseases (IBD) affect the function of pathogenic T helper 17 (Th17) cells. The research aims to: Use massively parallel reporter assays (MPRAs) to identify putatively causal IBD variants within the accessible...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to investigate the role of T helper cells and stem cells in colon homeostasis and tumor initiation. The $715,501 award to The Trustees of Columbia University, from March 2025 to January 2030, aims to: 1) determine whether T cell cytokines modulate colon stem cell function...
This Project Grant award, valued at $146,922.00 and issued on June 23, 2025, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at The Trustees of Columbia University in the City of New York, Health Sciences Division, to investigate how inhibiting the migration of immature neutrophils during obesity and weight loss affects...
This $249,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the molecular mechanisms controlling hematopoietic stem cell (HSC) fate choices, including symmetric self-renewal, symmetric commitment, and asymmetric divisions. The research aims to characterize the HSC-like intermediate state controlled by m6A RNA...
This Project Grant award of $224,088 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to train a postdoctoral fellow in experimental technologies and conceptual knowledge to become an independent academic researcher in gastrointestinal stem cell biology. The research will elucidate the mechanisms of Notch signaling in immature and adult intestinal stem cells that regulate stem cell and Paneth...

This federal Project Grant award of $645,617 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the Icahn School of Medicine at Mount Sinai to understand hematopoietic stem cell dysfunction in refractory Crohn's disease. The key objectives are to (1) profile hematopoietic stem cell populations associated with refractory Crohn's disease, (2) characterize hematopoietic stem cell functions linked to refractory disease and treatment outcomes, and (3) explore the poorly defined intestinal hematopoietic stem cell niche. This 5-year research project aims to advance the understanding of Crohn's disease therapeutic mechanisms beyond the traditional inflammation-focused paradigm.

Generated 8/5/25, 3:44 AM