Project Grant R01DK141825

Award Date 1/20/25
Completion Date 11/30/28
Dollars Obligated $965K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $850,232 to Northwestern University to advance the evolution of the Chicago Classification for diagnosing esophageal motor disorders. The project aims to develop new approaches combining assessments of esophageal neuromyogenic function and geometry to identify biomechanical physiomarkers of...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $594,956 to the University of South Florida to conduct research on the mechanisms underlying stretch-evoked activation of esophageal vagal afferents. The goal is to determine the mechanosensitive channels and sodium channels responsible for transducing esophageal stretch into vagal afferent...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a $389,578 multi-center clinical research project focused on improving the treatment of achalasia, a rare esophageal motility disorder. The project, titled "Precision Medicine in Achalasia - PREMEDIA", aims to test an innovative, tailored approach to per-oral endoscopic...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $1,222,594 to Vanderbilt University Medical Center to investigate the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment associated with eosinophilic esophagitis. The research aims to determine...
This federal Project Grant award of $524,837 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting research to investigate the role of enteric glial mechanotransduction and the impact of mechanical stress on postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to better understand the pathogenic mechanisms of POI in...
This $314,827 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund a randomized clinical trial to evaluate a modified vertical sleeve gastrectomy (MVSG) procedure compared to the conventional vertical sleeve gastrectomy (CVSG) for patients with obesity and gastroesophageal reflux disease (GERD). The study aims to determine if the MVSG technique...
This $475,605 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to definitively evaluate gastric dysrhythmia as a disease mechanism underlying functional dyspepsia and chronic nausea/vomiting syndromes, which affect over 10% of the population. The project will apply a novel non-invasive diagnostic approach called Body...
This $188,538 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Northwestern University to develop predictive modeling of chromatin packing domains for personalized biomarker discovery in ulcerative colitis. The goal is to establish a framework linking transcriptomic states with chromatin structure to advance biomarker development. The research project...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $708,138 to support the development of a biomechanocompatible small molecule-releasing scaffold for bladder augmentation. The goal is to create an alternative to conventional surgical approaches that use detubularized bowel tissue, which can have significant complications. The...
This federal Project Grant award of $454,155.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at the University of Rochester to investigate the role of the S100A4 protein in the development and resolution of post-operative abdominal adhesions. The research aims to comprehensively define the molecular mechanisms underlying adhesion formation, determine...

This Project Grant award of $964,718 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research will fund research at Northwestern University to develop and validate a "Virtual Esophagus" (VESOPHAGUS) simulation model. The goal is to leverage this model to define the physiomechanical factors driving poor outcomes in patients with achalasia and gastroesophageal reflux disease (GERD), and to use the model to predict surgical outcomes for treatments like peroral endoscopic myotomy (POEM) and anti-reflux surgery. The project aims to demonstrate how this personalized, physics-based simulation approach can guide treatment selection and improve prognosis for patients with esophageal disorders. The award period runs from January 2025 through November 2028.

Generated 8/5/25, 4:18 AM