This Project Grant award, totaling $184,572 and provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, aims to characterize the transmural nature of ulcerative colitis (UC) and its associated disease-related outcomes using intestinal ultrasound. The research will test the hypothesis that transmural structural alterations to the bowel wall in UC lead to poor clinical outcomes compared...
This Project Grant award of $949,056, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by Northwestern University to investigate the functional roles of the DDX41 gene in the homeostasis of G-quadruplexes during erythropoiesis. The research aims to elucidate the molecular and cellular mechanisms by which DDX41 mutations contribute to the...
This Project Grant award of $790,359.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to develop a targeted probiotic yeast therapeutic for treating inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. The award will fund the design, characterization, and optimization of a bioengineered Saccharomyces boulardii yeast that can secrete nanobody...
This $1,060,675.00 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at the University of Arizona focused on understanding how the pattern recognition receptor Absent in Melanoma 2 (AIM2) impacts intestinal stem cell differentiation and immune responses during inflammation. The project will utilize tissue-specific animal models, intestinal epithelial organoid...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $1,739,177 to The Leland Stanford Junior University to conduct research on the role of impaired cellular RNA editing in the etiology of inflammatory bowel disease (IBD). The research aims to: Leverage genetic data to prioritize double-stranded RNA (dsRNA) loci associated with IBD susceptibility and systematically assess how risk and protective alleles affect dsRNA editing....
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding the mechanisms by which microbially derived metabolites regulate host gut inflammation. The award period runs from August 28, 2024 to February 28, 2027. The research aims to determine the regulatory...
This $194,172 Project Grant, awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) on August 1, 2025, will fund research by Dr. Ruben Colman at Stanford University to elucidate the relationship between microbial metabolites and anti-TNF pharmacokinetics in pediatric Crohn's disease. The goal is to develop machine learning models that can predict endoscopic and transmural healing based on these pharmacodynamic markers, thereby enhancing precision medicine...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $859,704 to support research on how the endoplasmic reticulum (ER) protein AGR2 regulates host-microbe interactions and inflammatory responses in Crohn's disease. The research aims to elucidate the cellular and molecular mechanisms by which AGR2 deficiency leads to ER stress, bacterial dysbiosis, and...
This Project Grant award of $177,310, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research", supports research at the University of Florida to elucidate the transcriptional regulatory function of the nuclear receptor NR2F6 in T helper 17 (Th17) cells and its potential impact on inflammatory bowel disease (IBD). The key objectives are to: 1) Enumerate NR2F6's...