Project Grant R01DK138047

Award Date 9/20/24
Completion Date 7/31/27
Dollars Obligated $315K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Irvine, CA 92617, USA
Similar Awards
This $964,718 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support a research project titled "VESOPHAGUS - PREDICTING SURGICAL OUTCOMES USING A VIRTUAL ESOPHAGUS". The primary objective is to utilize a virtual esophagus simulation model, known as VESOPHAGUS, to define the physiomechanical factors driving poor outcomes in patients...
This $539,220 federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the role of rapid nutrient delivery in driving gut-brain axis signaling and sustained weight loss after bariatric surgery. The project will test the hypothesis that rapid nutrient delivery is associated with augmented GLP-1 and brain fMRI responses, as...
This federal Project Grant award in the amount of $475,605.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is focused on evaluating gastric dysrhythmia as a disease mechanism for functional dyspepsia and chronic nausea and vomiting syndromes. The project will apply a novel Body Surface Gastric Mapping (BSGM) technique, which uses flexible electrode arrays and advanced...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to leverage the gastric submucosa as a host for cell therapies. The $255,828 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated, will support research to better understand submucosal biology and evaluate the potential of using the gastric...
This $497,016 federal Project Grant award under the National Institute of Diabetes and Digestive and Kidney Diseases' (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to improve perioperative health outcomes for patients with end-stage kidney disease who require surgery. The principal investigator, Dr. Vikram Fielding-Singh, will conduct research to evaluate the link between modifiable preoperative dialysis parameters and postoperative...
This $1,349,708 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research" will fund a randomized controlled trial to evaluate a mechanism-guided strategy for managing laryngopharyngeal reflux (LPR) compared to the standard proton pump inhibitor (PPI) approach. The key products and services to be delivered include: Conducting a randomized trial (n=160)...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $645,574 to Syntis Bio Inc. to develop an oral pill that mimics the effects of gastric bypass surgery. The goal is to create a once-daily oral medication that can block nutrient absorption in the duodenum, thereby replicating the weight loss benefits of Roux-en-Y gastric bypass surgery...
This federal Project Grant award of $454,155 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the S100A4 protein in the formation and resolution of post-operative abdominal adhesions. The University of Rochester will leverage preclinical mouse models to comprehensively define the molecular mechanisms driving adhesion...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $108,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Medical University of South Carolina (MUSC). The funding will support the MUSC GI and Hepatology Medical Student Training Program, which aims to engage medical students in high-quality research related to gastrointestinal and liver diseases. The program will provide focused research...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a $389,578 multi-center clinical research project focused on improving the treatment of achalasia, a rare esophageal motility disorder. The project, titled "Precision Medicine in Achalasia - PREMEDIA", aims to test an innovative, tailored approach to per-oral endoscopic...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop and test a modified vertical sleeve gastrectomy (MVSG) surgical procedure to minimize gastroesophageal reflux disease (GERD) associated with the conventional vertical sleeve gastrectomy (CVSG) procedure. The $314,827 award, effective from September 20, 2024 to July 31, 2027, will fund a randomized, single-blind clinical trial at two academic sites to compare outcomes between the MVSG and CVSG procedures. The study will measure acid exposure time, lower esophageal sphincter function, and quality of life to determine if the MVSG leads to improved GERD outcomes compared to the standard CVSG. This pilot study will generate data to support the design of a larger, multi-site definitive clinical trial on this surgical innovation.

Generated 6/24/25, 6:23 AM