Project Grant R01DK140371
- This Project Grant award, totaling $377,648, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research on the role of Proteus mirabilis RTX proteins in polymicrobial biofilm formation and the pathogenesis of catheter-associated urinary tract infections (CAUTIs). The research aims to examine the expression of P. mirabilis RTX proteins during polymicrobial biofilm...
- This Project Grant award of $226,253 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the adaptations of Staphylococcus aureus that enable its persistence within the bladders of long-term catheterized individuals. The research will be conducted by the University of Texas Health Science Center at Houston (UTHealth) from September 1, 2025 through...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $234,750 to the University of Notre Dame to conduct research on polymicrobial interactions during catheter-associated urinary tract infections (CAUTI). The key objectives are to: Investigate the antagonistic effects of Escherichia coli (E. coli) against Candida albicans (C. albicans), specifically examining the...
- This $117,000 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to the Research Institute at Nationwide Children's Hospital. The project aims to define the mechanisms by which the transcription factor STAT3 contributes to antimicrobial host defense in the human urothelium (bladder lining) against urinary tract infections (UTIs). Key...
- This $2,833,514 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Renal Metabolism in AKI", will fund research to investigate changes in kidney metabolism in sepsis-associated acute kidney injury (AKI) and their impact on kidney tubule injury and recovery. The University of California, San Diego (UCSD) is the awardee...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is providing $173,664 to The Regents of the University of California, San Francisco (UCSF) to conduct research on "Molecular Characterization of Ascites Fluid to Identify Drivers of Infection in Patients with Decompensated Cirrhosis." The project aims to apply metagenomic...
- This Project Grant award, in the amount of $126,846, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a translational research project to investigate the role of the gut microbiome in the pathogenesis of sepsis-associated acute kidney injury (AKI). The research, to be conducted at the University of Michigan, aims to identify gut bacteria...
- This Project Grant award, valued at $126,460 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify ecological drivers of dysbiosis in the female reproductive tract. The research will use genetically tractable uropathogenic E. coli and specialized animal and tissue culture models to determine how host cell metabolism controls vaginal community composition and perpetuates...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $714,748 to The Research Foundation For The State University Of New York, operating as Upstate Medical Center, to support research investigating the role of blood flow shear stress in the development of systemic amyloidosis. The project aims to utilize microfluidic devices that mimic the branched structure...
- This $3,400,004 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of waterborne Escherichia coli transmission as a cause of community-acquired urinary tract infections (UTIs). The key objectives are to: (1) model the drivers and dynamics of E. coli contamination in water systems, (2) identify socio-behavioral, epidemiological, genomic, and...
This $809,427 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the impact of polymicrobial interactions and within-host adaptation on the pathogenesis of catheter-associated urinary tract infections (CAUTI). The award recipient, The Research Foundation For The State University Of New York (RF SUNY) doing business as Sponsored Projects Services, will investigate how the interactions between the three most common and persistent CAUTI pathogens - Enterococcus faecalis, Proteus mirabilis, and Escherichia coli - affect biofilm formation and infection severity. The project aims to address the substantial knowledge gap around how microbe-microbe interactions and within-host adaptation influence the progression from initial colonization to urosepsis and the development of antimicrobial resistance. The award period runs from Sep 9, 2025 to Jun 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $15.0k | 9/17/25 | ||
| Not listed | $794.4k | 9/3/25 |