Project Grant R01DK146350

The National Institute of Diabetes and Digestive and Kidney Diseases, a component of the Department of Health and Human Services National Institutes of Health, awarded $674,691 to the Trustees of Indiana University (doing business as Indiana University Indianapolis) on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847).

The award funds research investigating alternative splicing of uromodulin (AS-UMOD) as a protective mechanism against acute kidney injury (AKI) in thick ascending limb cells. The research will establish the spatiotemporal dynamics of AS-UMOD during AKI and its targeting to the mitochondria; demonstrate that AS-UMOD enhances mitochondrial function by improving activity of SLC25 carriers across the inner membrane; and establish the protective functions and metabolic impact of AS-UMOD during kidney injury. The work will also explore splice-switching oligonucleotides as a potential novel therapeutic strategy for AKI.

Performance of work is located in Indianapolis, Indiana. The period of performance extends through March 31, 2030. The assistance type is a Project Grant, which supports basic and clinical biomedical research to improve understanding of disease mechanisms and develop improved prevention, diagnosis, and treatment strategies for diabetes, digestive, and kidney diseases.