The Children's Hospital Corporation, doing business as Boston Children's Hospital, has been awarded a $696,870 Project Grant by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research to functionally characterize the endothelial cell niche that supports hematopoietic stem cells, with the goal of developing new approaches to expand and maintain these cells for the treatment of blood disorders. Key research activities include comparing single-cell RNA sequencing analyses of adult liver and marrow sinusoids across species, overexpressing transcription factors to reprogram ectopic regions into hematopoietic supportive niches, and using chemical genetics to define the mechanisms by which lipid signaling regulates endothelial cell support of stem cell division and self-renewal. The project will run from August 1, 2024 to May 31, 2028.
Generated 3/4/25, 7:00 AM