This federal Project Grant award for $254,990.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to understand kidney endothelial maturity and mesenchymal transition in vascularized human kidney organoids. The key objectives are to: 1) examine whether co-culturing engineered endothelial cells in kidney organoids enables...
This $543,826 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop novel bioengineered regenerative medicine solutions for vascular tissue engineering. The research project, conducted at the University of Pittsburgh, focuses on understanding the mechanisms behind injury-inducible, in vivo vasculogenic reprogramming using a...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is providing $499,890 to Pavaj Vascular Corporation to develop a novel therapy to prevent arteriovenous fistula (AVF) venous stenosis and improve outcomes for patients with end-stage kidney disease (ESKD) requiring hemodialysis. The primary objectives are to: 1) Evaluate the stability and...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of intracellular iron dysregulation in kidney fibrosis and potential therapeutic approaches for chronic kidney disease (CKD). The $199,922 award will fund a 1-year study conducted by Weill Medical College of Cornell University to define the...
This Project Grant award of $114,594 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research to investigate the use of pulsed ultrasound targeted to the spleen as a non-pharmacological approach to delay the progression of chronic kidney disease (CKD) through activation of the cholinergic anti-inflammatory pathway. The research, to be...
This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the protective role of the transcription factor KLF2 in diabetic kidney disease (DKD) and explore its potential as a therapeutic target. The $740,566 award, effective from September 2024 through May 2029, will support research to: 1) determine how KLF2 is regulated in...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $155,274 to Emory University to support a research project titled "Neurovascular Mechanisms of Kidney Disease Progression in Older Adults." The primary objectives of this 4-year research project are to identify neural and vascular mechanisms contributing to accelerated...
This federal Project Grant award, valued at $748,625.76, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at the University of California, San Francisco (UCSF) focused on the "Translational Regulation of PGC1alpha and Oxidative Metabolism." The project aims to advance scientific understanding of the mechanisms underlying...
This federal Project Grant award of $209,832 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program supports research to investigate the role of the autonomic nervous system in the cardiovascular complications of chronic kidney disease (CKD). The primary objectives are to: 1) Deeply phenotype autonomic dysfunction in CKD using comprehensive testing; 2) Quantify the association...
This $400,000 Project Grant was awarded on September 9, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will support research at the University of Texas Southwestern Medical Center to understand the earliest stages of podocyte injury in collagen IV nephropathies, which can lead to chronic kidney disease and end-stage renal failure. The research aims to...