The National Science Foundation (NSF) awarded a 3-year, $567,284 Project Grant under the Engineering program (CFDA 47.041) to Purdue University to develop a scalable Bayesian methodology for reconstructing cardiovascular hemodynamic flow fields and cardiac structure from advanced medical imaging modalities like phase-contrast MRI, 4D flow MRI, and color Doppler echocardiography. The research aims to overcome limitations in current imaging techniques, such as inaccurate velocity flow...
The National Science Foundation (NSF) awarded a $400,000 Project Grant under the Engineering program (CFDA 47.041) to the New Jersey Institute of Technology (NJIT) to advance the understanding of how new blood vessels grow in the body. This 3-year project aims to develop data-driven models that integrate high-fidelity biophysical simulation with high-resolution imaging of real blood vessel networks undergoing growth and adaptation. The research will elucidate the fluid dynamics and biophysics...
This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) project grant award provides $598,884 over 4 years to The Regents of the University of California, doing business as the University of California, Berkeley, to develop a novel suite of simulation tools for modeling vascular biomechanics and mechanobiology as part of the open-source SimVascular software platform (CFDA No. 47.041 Engineering). The project aims to enhance...
This $350,000 National Science Foundation project grant supports research at the University of Virginia from October 1, 2022 to September 30, 2025 under the NSF Engineering program (CFDA 47.041). The research aims to advance understanding of the effects of microgravity on wound healing processes by leveraging a sensor-integrated 3D tissue culture model. Specifically, the project will explore dynamic changes in gene and protein expression, endothelial network formation, and extracellular matrix...
This $635,000 Project Grant awarded by the National Science Foundation (NSF) Division of Civil, Mechanical, and Manufacturing Innovation supports research to understand how mechanical boundary conditions influence tissue assembly and repair in 3D fibrous microtissues. The research aims to advance knowledge about the mechanisms by which mechanical forces regulate new tissue formation and organization, particularly as it relates to wound healing. The project will integrate in vitro experiments and...
The National Science Foundation (NSF) Office of Advanced Cyberinfrastructure awarded a 4-year, $1,000,899 Project Grant to The Leland Stanford Junior University (Stanford University) under the NSF's Computer and Information Science and Engineering (CISE) program (CFDA 47.070). The project aims to develop and publicly release a novel suite of multifidelity simulation tools for modeling vascular biomechanics and mechanobiology in the open-source SimVascular project. Specifically, the grant will...
This $506,803 Project Grant awarded by the National Science Foundation's Engineering program (CFDA 47.041) supports research to develop multiscale computational models for predicting thrombus (blood clot) formation and its response to external loads. The award to The Research Foundation for the State University of New York (RF SUNY) aims to advance understanding of clot growth and rupture under different blood flow conditions. The research will integrate experimental validation using 3D...
This federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $349,237 to support collaborative research on the role of tension in the digestion of blood clots. The research aims to investigate how inherent and applied tension regulate the fibrinolytic process, which is critical for avoiding blood vessel occlusion during wound healing. The project will take a multidisciplinary, multi-institutional approach, involving tensile testing,...
This three-year, four hundred thirty-five thousand eight hundred forty-five dollar ($435,845) Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will support Carnegie Mellon University's efforts to advance biom anufacturing of vascularized adipose tissues. Specifically, the university aims to address engineering challenges in producing large, high-density human adipose tissues with integrated, perfusable vascular...
This $500,000 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the University of Notre Dame's research exploring the differentiation of stem cells into patterned blood vessel networks using hybrid memristor technology. Over a four-year period from October 2022 to September 2026, the University will engineer the first autonomous hybrid memory resistor and cell culture device to control human pluripotent stem cell differentiation into...