Project Grant R01DK141129

This federal Project Grant award, identified as R01DK141129, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $575,394 grant supports research to investigate the role of A-kinase anchoring proteins (AKAPs) and mutant forms of the catalytic subunit of protein kinase A (PKAC) in driving adrenal Cushing's syndrome, an endocrine disorder characterized by excess cortisol production. The research, which will be conducted at the University of Washington, aims to evaluate the frequency and impact of a newly discovered PKAC-W196G mutation, as well as test if anchored type I PKA signaling predominates in adrenal Cushing's syndrome. This work is expected to provide insights into the underlying molecular mechanisms and potential therapeutic approaches for addressing this rare but debilitating disease. The grant period runs from September 1, 2024, through May 31, 2029.