This $142,902 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to uncover the mechanism by which the regulatory GTPase ARL13B drives polycystic kidney disease (PKD) pathogenesis. The research, led by Dr. Van Sciver at Emory University, will biochemically and genetically dissect ARL13B's interaction with three effector proteins - CDK1, ARL3,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research into the mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD). The $1,472,604 award to the Children's Hospital Medical Center in Cincinnati, OH aims to elucidate how a second somatic mutation in renal cells affects their behavior and the progression of cystic disease in...
This $492,329 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the FBW7 gene in the development of cystic kidney diseases. The project aims to enhance understanding of the cellular mechanisms driving cyst formation, fibrosis, and tubular degeneration, with the goal of identifying new therapeutic targets...
The University of Pittsburgh received a $198,750 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a rapid, quantitative platform using yeast to classify how approximately 70 identified mutations in the polycystin-1 (PC1) protein disrupt channel activity with PC2. This research aims to provide new reagents and assays to the scientific and PKD (polycystic kidney disease) community to study the molecular defects of PC1 mutants. The...
This federal Project Grant award of $640,001.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, which runs from January 1, 2025 to November 30, 2028, supports research conducted by Yale University to explore the mechanisms by which the protein polycystin-1 (PC1) and its C-terminal fragments affect mitochondrial function and cellular energy...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $135,582 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Oklahoma Health Sciences Center to construct a single-cell atlas of mouse and human cells in autosomal dominant polycystic kidney disease (ADPKD). The project aims to understand how molecular and cellular pathways found in ADPKD patients correlate to mouse models, and to identify inter-...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $225,304 to Northwestern University for research on polycystin proteins and their role in autosomal dominant polycystic kidney disease (ADPKD). The primary goals of this project are to: 1) Characterize the functional consequences of ADPKD disease-causing variants in the PKD2 gene using...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $223,918 to the University of Oklahoma Health Sciences Center to study "Targeting Kidney Resident Macrophage Niche Filling to Slow Cystic Kidney Disease". The project aims to understand the mechanism of kidney resident macrophage (KRM) niche filling after temporary depletion and identify factors like...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $2,029,830 to the University of Utah to conduct research on the structural mechanisms and functional properties of polycystin proteins associated with polycystic kidney disease, biliary atresia, and congenital heart defects. The key objectives are to: 1) determine the structures and stoichiometry of various...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $504,621 to The University of Texas Southwestern Medical Center to investigate intracellular cholesterol biosynthesis as a regulator of polycystic kidney disease (PKD) progression. The research aims to: 1) determine if reducing intracellular cholesterol by inhibiting de novo synthesis or uptake aggravates...