This $893,788.54 R01 research project grant was awarded on May 1, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Augusta University Research Institute, Inc. to investigate the role of neddylation, a post-translational protein modification, in regulating mitochondrial function and adipose tissue maintenance. The key objectives are to establish the significance of neddylation in adipose tissue remodeling and energy homeostasis, and to dissect the molecular mechanisms by which neddylation targets the CUL3 E3 ubiquitin ligase to mediate adipocyte mitochondrial function and turnover. This research aims to provide fundamental insights into how post-translational modifications influence adipose tissue pathophysiology and its implications for metabolic disorders like obesity and lipodystrophy.
Generated 2/25/25, 4:22 AM