This $142,902 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to uncover the mechanisms by which the regulatory GTPase protein ARL13B drives kidney cyst formation in polycystic kidney disease (PKD). The research, led by Dr. Van Sciver at Emory University, aims to identify the critical interactions between ARL13B and three key...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $640,001 to Yale University to conduct research on polycystin-1 (PC1) and its role in autosomal dominant polycystic kidney disease (ADPKD). The key objectives are to: Determine whether expressing a specific fragment of PC1 (P200) can suppress cyst formation and reverse established...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $2,029,830 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Utah to conduct research on the structural mechanisms of polycystic kidney disease (PKD) proteins. The project aims to: 1) determine the structures and stoichiometry of PKD1/PKD2, PKD1L1/PKD2, and PKDREJ/PKD2L2 protein complexes, and define their channel properties to understand their...
This Project Grant award for $504,621 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to investigate the role of intracellular cholesterol biosynthesis in regulating the progression of autosomal dominant polycystic kidney disease (ADPKD). The research, to be conducted by The University of Texas Southwestern Medical Center, aims to determine if reducing...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to characterize the functional consequences of disease-causing variants in the PKD2 gene associated with autosomal dominant polycystic kidney disease (ADPKD). The $225,304 award to Northwestern University will fund research using a novel synthetic biology approach to investigate the...
This federal Project Grant award of $587,212 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to investigate the role of the protein CDKN1A (P21) in the development and progression of polycystic kidney disease (PKD). The University of Alabama at Birmingham (UAB) is conducting this research to understand how dysregulation of P21, a key cell cycle regulator, may...
The University of Pittsburgh received a $198,750 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a rapid, quantitative platform using yeast to classify how approximately 70 identified mutations in the polycystin-1 (PC1) protein disrupt channel activity with PC2. This research aims to provide new reagents and assays to the scientific and PKD (polycystic kidney disease) community to study the molecular defects of PC1 mutants. The...
The University of Oklahoma Health Sciences Center was awarded a $135,582 Project Grant under the National Institute of Diabetes and Digestive and Kidney Diseases' (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Constructing Mouse and Human Single-Cell Atlas in Autosomal Dominant Polycystic Kidney Disease", aims to generate new single-cell RNA sequencing data in a mouse model and integrate it with existing mouse data to...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $223,918 to the University of Oklahoma Health Sciences Center to study mechanisms of kidney resident macrophage niche filling as a potential approach to slow the progression of autosomal dominant polycystic kidney disease (ADPKD). The central hypothesis is that temporarily...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $492,329 to the University of Oklahoma Health Sciences Center to conduct research on the role of the FBW7 protein in cystic kidney diseases. The research aims to enhance the understanding of cellular mechanisms driving cystogenesis, fibrosis, and tubular degeneration in polycystic...