The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $598,609 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, MA. The grant, running from September 20, 2024 to July 31, 2029, aims to clinically evaluate mechanisms of resistance to the 5α-reductase inhibitor finasteride, a common drug used to manage benign prostatic hyperplasia (BPH) and...
This $1,350,373 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the role of lipid accumulation and foam cells in benign prostate disease. The project, conducted by Old Dominion University and its research foundation, aims to: 1) investigate the impact of the cytokine CXCL17 on the prostatic immune environment in mice...
This Project Grant award, valued at $629,250.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to examine the role of hyaluronic acid (HA) in the pathobiology of benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS). The primary objectives are to characterize the relationship between HA,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,428,186.00 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to conduct research on the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans. The project aims to biochemically characterize N-acyl amino acids as substrates and inhibitors of CYP4F...
The National Institute on Aging (NIA) awarded a $489,509 Project Grant (CFDA 93.866 - Aging Research) to the Magee-Womens Research Institute And Foundation to conduct research on steroid hormone pathways regulating benign prostate hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with aging. The 2-year project aims to: Identify proteins and pathways involved in promoting smooth muscle relaxation and bladder voiding that are dysregulated in aged mouse prostate models and...
This $337,284 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support the development of a novel "Precision-Cut Bladder Slice" (PCBS) technology at Boston Children's Hospital. The goal is to enable quantitative assessment of bladder smooth muscle contraction, relaxation, and stiffness in both healthy murine and human tissues, while...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
This federal Project Grant award of $1,600,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at Beth Israel Deaconess Medical Center, Inc. (BIDMC) to develop a computational pharmacology approach for coordinating the regulation of multiple neuron types related to energy balance and satiety. The research aims to identify combinations of 2-10 ligands...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $191,234 to Beth Israel Deaconess Medical Center, Inc. over the period of August 1, 2025 to July 31, 2030. The funding supports research to examine the role of gastric dopaminergic signaling and gastrointestinal mucosal injury in Parkinson's disease. Key objectives include investigating...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at Brigham Young University to determine the role of the NR4A1 gene in pathways that expand functional beta cell mass as a potential treatment for type 1 and type 2 diabetes. The $568,075 award, with a project period from Jul 1, 2025 to Jun 30, 2028, will fund studies to...