This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA Program 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, will provide $1,331,148 to Yale University over 4 years starting June 1, 2025. The grant will fund research to investigate the mechanisms by which pancreatic alpha-cells compensate for beta-cell mass deficiency in type 2 diabetes. The project aims to determine the signaling pathways and functional...
This Project Grant award of $444,867.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The goal is to elucidate the pathological impact of XBP1s on beta cell integrity in the context of type 2 diabetes progression, in order to...
This federal Project Grant award, valued at $567,643.00 and awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research aimed at enhancing our understanding of the complex metabolic roles of glucagon and its impact on alpha-to-beta cell communication in the context of type 2 diabetes. The research objectives include utilizing preclinical studies in human...
This $1,338,684 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports a longitudinal study to utilize PET and MRI techniques to assess insulin vesicle functional capacity, beta cell mass, and pancreas volume in individuals at risk for and with recent onset type 1 diabetes. The goal is to provide a comprehensive picture of multiple measures of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to systematically evaluate the molecular cascade involving Type 2 diabetes (T2D) effector genes, the transcription factors RFX3/6, and T2D-associated genetic variants in human islet cell generation, survival, and function. The $561,893 award, with a period of performance...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at the Joslin Diabetes Center to investigate the impact of glucose toxicity on beta-cell function and translational regulation. The $2,155,558 award, spanning from Aug 2, 2024 to May 31, 2027, will test the hypothesis that glucose toxicity leads to dysregulation of...
This $205,280 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the mechanisms driving the kinetics of incretin-mediated beta cell responses. The primary awardee, the University of California, Davis, will leverage novel transgenic mouse models and genetically encoded sensors to investigate how incretin receptor...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,057,854 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Trustees of the Colorado School of Mines, doing business as Colorado School of Mines. The grant is titled "The Role of the Pancreas Microenvironment in Regulating Islet Function and Survival in Type 1 Diabetes" and aims to investigate the role of the peri-islet extracellular...
This $1,333,072 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the cellular mechanisms underlying beta-cell dysfunction in type 2 diabetes. The primary awardee, the University of Iowa, will lead studies to define the role of altered endoplasmic reticulum (ER) redox homeostasis in impairing proinsulin folding...
This federal Project Grant award of $1,198,635.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to investigate the role of the signaling protein 14-3-3ζ in regulating islet cell function and crosstalk between α-cells and β-cells. The research, to be conducted by the University of California, Davis, aims to determine how 14-3-3ζ in β-cells...