This Project Grant award of $273,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at Rockefeller University to investigate the role of phospholipid homeostasis in cellular and organismal physiology. The key objectives are to: 1) study the influence of the choline transporter FLVCR1 on organismal metabolism and its potential as a therapeutic...
This $243,590 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at the University of Chicago to investigate the role of the protein BNIP3 in regulating lipid metabolism and fat accumulation in the liver. The research aims to elucidate the mechanisms by which BNIP3 promotes mitophagy (selective degradation of mitochondria) and...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
This $391,250 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research on extracellular vesicle-dependent RNA signaling in metabolism. The project aims to identify key proteins involved in the delivery of adipose microRNAs into liver cells via extracellular vesicles, and to determine if this RNA delivery mechanism is necessary for...
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
This $511,336 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to determine the mechanisms, therapeutic potential, and regulation of a liver-specific mitochondrial carrier protein called SLC25A47. The research aims to understand how inhibiting SLC25A47 can limit...
This Project Grant award for $1,521,924.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to understand how changes in the architecture of the endoplasmic reticulum (ER) within liver cells contribute to metabolic dysfunction and fatty liver disease. The research aims to: 1) Determine the role of the RRBP1 protein in regulating...
This federal Project Grant award, valued at $748,625.76, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant was awarded to The Regents of the University of California, San Francisco on Aug 2, 2024, with a final completion date of Jul 31, 2027. The funding supports a research project focused on "Translational Regulation of PGC1alpha and Oxidative...
This Project Grant award, worth $492,409, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to evaluate the role of the creatine pathway in regulating intestinal goblet cell development and its impact on the microbiome and susceptibility to colitis. Specifically, the research will investigate the contribution of glycolysis on goblet cell...
This federal Project Grant award of $637,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to explore the production and signaling properties of novel bile acids produced by the gut microbiome. The project aims to 1) define the microbiology of microbially conjugated bile acid (MCBA) production, 2) determine the agonist activity of MCBAs on the...