The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $151,643 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Colorado-Denver. The grant supports research to develop proteolysis targeting chimeras (PROTACs) that can stabilize hypoxia-inducible factors (HIF) to enhance barrier formation and wound healing in inflammatory bowel disease models. The project aims to elucidate the...
This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), supports research to investigate the epithelial-specific roles of the antioxidant protein glutathione peroxidase 1 (GPX1) in the intestinal microenvironment. The $116,625 award, effective March 12, 2025 through February 28, 2027, will be used by the University of Iowa to develop a novel mouse model allowing for cell...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $551,112 to Children's Hospital Los Angeles (CHLA) to elucidate the role of deep crypt secretory (DCS) cells in colonic inflammation and tissue repair. The project aims to 1) determine if impaired DCS cell responses exacerbate colonic inflammation and limit tissue regeneration, 2)...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $163,825 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to investigate the role of the AXL signaling pathway in the development of intestinal fibrosis associated with Crohn's disease. The research aims to unravel the intricacies of the GAS6/AXL signaling axis and...
This Project Grant award of $1,328,326.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the regulation of CD39 expression in gamma delta intraepithelial lymphocytes (gd IELs) and its impact on immunometabolism and function. The research aims to elucidate the mechanisms by which CD39 expression is regulated in gd IELs, understand the coupling between CD39 and gd IEL...
This $220,930 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate the role of the protein myosin 5B in regulating intestinal microvilli assembly and susceptibility to bacterial infection in Crohn's disease. The research aims to elucidate how myosin 5B trafficking of intermicrovillar adhesion complex (IMAC) proteins impacts microvilli...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $533,907.00 to Rutgers, The State University to investigate the role of the epigenetic regulator TET3 in protecting intestinal epithelial cells against inflammatory stressors. The project aims to decipher the mechanisms by which TET3-mediated DNA oxidation and transcriptional...
This Project Grant award, ID R01DK137771, is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program. The $1,882,623 award will support research at the Cincinnati Children's Hospital Medical Center to investigate the epigenetic regulation of intestinal tuft cells and how microbial metabolites influence their development and function. The research aims to uncover novel...
This Project Grant award, totaling $233,600.00 and spanning September 1, 2024 to June 30, 2027, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD), a debilitating condition characterized by chronic inflammation and erosion of intestinal functions. The...
This Project Grant award of $168,330 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Yale University to elucidate the fate specification of CFTR high expresser (CHE) cells in the intestine. The goal is to define the transcriptional network driving CHE cell fate specification and the role of Notch signaling in this process, using a novel rat intestinal organoid model. This...