This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
This $243,590 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at the University of Chicago to investigate the role of the protein BNIP3 in regulating lipid metabolism and fat accumulation in the liver. The research aims to elucidate the mechanisms by which BNIP3 promotes mitophagy (selective degradation of mitochondria) and...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at the Pennington Biomedical Research Center to examine the role of the mitochondrial protein SLC25A25 in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)....
This $800,000 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to develop new combinatorial pharmacology approaches for regulating multiple neuron types in the brain to effectively promote satiety and reduce body weight in mouse models of obesity. The research aims to...
The federal Project Grant award R01DK137983, totaling $1,428,186, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This grant supports research to define the role of a unique class of lipid signaling molecules called N-acyl amino acids in human metabolism and their relationship to obesity, type 2 diabetes, and cardiovascular disease. The research will...
This $806,452 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research investigating the mechanisms that combine type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The research aims to determine how hepatic insulin resistance can lead to the progression of NAFLD to the more severe non-alcoholic steatohepatitis (NASH), and how this...
This federal Project Grant award of $646,070.00 was awarded on September 15, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The primary awardee is Rockefeller University, a private research university in New York City. The grant will fund research to investigate the physiological and molecular functions of choline transport in mammals, focusing on the role of the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $172,060 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The project aims to understand the mechanism by which the Unfolded Protein Response (UPR) is dysregulated in the pathogenesis of Non-Alcoholic Steatohepatitis (NASH), a leading cause of liver...
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,618,520 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Pittsburgh. The grant, titled "Defining the Molecular Regulation and Physiological Role of a Novel Lysosomal Mechanism of Adipocyte Lipolysis," aims to investigate an alternative lysosomal pathway for fatty acid release from adipocytes during fasting. The research...