This Project Grant award for $121,875.00, awarded on April 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), aims to investigate the developmental origins and regulatory mechanisms of dermal adipose tissue (DWAT), a distinct and understudied component of the subcutaneous adipose depot. The research will utilize mouse models, advanced transcriptomic techniques, metabolic phenotyping, and human adipose tissue samples to address long-standing questions...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $499,761 to Albert Einstein College of Medicine to study the role of melanocortin pathways in the medial prefrontal cortex and their influence on feeding behavior and obesity. The 5-year award, spanning from December 2024 to November 2029, will utilize cutting-edge approaches in...
This $578,060 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to study a potential new enhancer region that activates the UCP1 gene, which is critical for thermogenesis and energy expenditure. The research will examine how this enhancer functions to increase UCP1 transcription, as well as assess its impact on thermogenesis, adiposity, and...
This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...
This federal Project Grant award of $800,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to discover new signaling molecules called "mammokines" that may play critical roles in the communication between the mammary gland and other organs like the liver, pancreas, and adipose tissue. The research seeks to understand how the secretome of the mammary...
This federal Project Grant award, valued at $450,000.00 and awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to elucidate the roles of the lysine acetyltransferase KAT8 in adipocyte function and its impact on lipoatrophy and systemic insulin resistance. The long-term objective is to understand how adipocyte KAT8 contributes to adipose tissue function and...
This $800,000 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to develop new combinatorial pharmacology approaches for regulating multiple neuron types in the brain to effectively promote satiety and reduce body weight in mouse models of obesity. The research aims to...
This $1,040,519 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to establish the significance of the hypothalamic protein JMJD3 in regulating leptin signaling and energy homeostasis. The award will fund research at Arizona State University to: 1) Examine whether hypothalamic JMJD3 protects against obesity through an epigenetic mechanism,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $519,068 to Mayo Clinic to conduct research on the role of the circadian system in regulating adipose tissue function in humans. The key objectives are to: 1) establish whether human subcutaneous adipose tissue exhibits autonomous circadian rhythmicity independent of diurnal...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $570,268 to Albert Einstein College of Medicine to study the regulation of adipose tissue remodeling by the CCNC-Mediator complex. The central hypothesis is that the CCNC subunit of the Mediator complex regulates nutritional and environmental cues that drive white adipose tissue (WAT) remodeling through both cell-autonomous and liver-WAT crosstalk mechanisms. The proposed research aims to investigate the WAT cell-autonomous mechanisms and metabolic functions of enhanced WAT browning upon CCNC deficiency, as well as the cellular and molecular mechanisms for liver CCNC regulation of WAT remodeling in mouse models of diet-induced obesity and cold exposure, with a focus on the role of liver-derived PDGF-AA. This research seeks to yield novel insights into the role of the human BMI-associated CCNC surface of the Mediator complex in regulating metabolism, establishing a foundation for future studies on obesity and type 2 diabetes.