This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will provide $450,000.00 to the Pennington Biomedical Research Center to elucidate the roles of the adipocyte protein KAT8 in regulating fat cell function, adipose tissue production of reactive oxygen species, and the adipose tissue microenvironment. The research aims to enhance...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $604,853 to Rockefeller University to conduct a systems-based investigation of the genetic determinants of human brown adipose tissue (BAT) function. The research aims to discover genetic variants that explain BAT regulation and link it to cardiometabolic traits and disease...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the relationship between hypothalamic microglia activation and perineuronal net loss in the pathogenesis of diet-induced obesity. The $176,500 award to the University of Washington will support studies aimed at quantifying the role of microglia in...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $173,523 Project Grant to Mayo Clinic under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund a multi-year (2024-2029) research project to define the molecular and systemic role of the intrinsic adipocyte (fat cell) circadian clock and how it is impacted by obesity in humans. The research aims to establish whether human subcutaneous adipose tissue...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $255,320 to the University of Pittsburgh to conduct research on the role of insulin-like growth factor 2 (IGF2) in regulating adipocyte progenitor proliferation and adipogenesis. The key objectives are to: 1) Determine whether IGF2 regulates adipocyte progenitor proliferation ex vivo, and...
This $578,060 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 "Diabetes, Digestive, and Kidney Diseases Extramural Research" is supporting research to elucidate the role of a previously uncharacterized enhancer region upstream of the UCP1 gene in regulating thermogenesis and energy expenditure. The University of California, Berkeley (UC Berkeley) is the prime awardee and will study histone modifications, promoter...
This federal Project Grant award, totaling $1,539,044.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate how obesity and type 2 diabetes impact pulmonary and extra-pulmonary immune responses, particularly in the context of respiratory viral infections like SARS-CoV-2 and influenza. The research is being conducted by...
This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a novel adipocyte engineering technology for modeling adipocyte dysfunction in human obesity. The $295,923 award to Mellicell Inc., a for-profit organization located in Newtonville, MA, will support two key milestones. Milestone 1 will compare the differentiation,...
The University of Utah was awarded a $119,341 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, to investigate the role of primary cilia signaling in adipogenesis and adipose tissue expansion. The two-year research project aims to define the necessity and sufficiency of compartmentalized cAMP signaling within primary cilia for preadipocyte differentiation, as well as...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), funded under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the regulation of adipose tissue remodeling by the CCNC-Mediator complex. The $570,268 award to the Albert Einstein College of Medicine, which runs from January 1, 2025 to December 31, 2029, will pursue two specific aims: 1) studying the white adipose tissue...