This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,329,941 to The Regents of the University of California, Berkeley (UC Berkeley) to conduct research on the role of biomechanical interfaces created by focal adhesion kinase in catecholamine signaling. The research aims to elucidate how biomechanical forces regulate beta-adrenergic receptor signaling in beige...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $840,198 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Dana-Farber Cancer Institute, Inc. (Dfci) in Boston, MA. The goal of this 4-year project is to better understand the mechanisms of energy expenditure and adipose thermogenesis in mammalian systems, with a focus on the futile creatine cycle pathway. Key objectives include determining how...
This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the structural basis of thermogenic mitochondrial respiratory complexes and their role in adipocyte function, obesity, and type 2 diabetes. The $813,511 award to Dana-Farber Cancer Institute, Inc. will fund a 4-year research project to: 1) Characterize the...
This Project Grant award of $604,853 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will fund research at Rockefeller University to elucidate the genetic determinants of human brown adipose tissue (BAT) function. The goal is to develop a better understanding of how BAT, which can protect against obesity and associated metabolic diseases, is regulated in humans. The research will leverage...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $136,449 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Regents of the University of California, Berkeley. The award, which runs from December 1, 2024 to November 30, 2026, will fund research to optimize the use of CRISPR-mediated gene downregulation to rapidly test whether genes linked to human obesity are required for the function of...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $570,268 to the Albert Einstein College of Medicine to conduct research on the regulation of adipose tissue remodeling by the CCNC-Mediator. The research aims to study the cell-autonomous mechanisms and metabolic functions of enhanced white adipose tissue browning, as well as the cellular...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $124,536 to investigate the role of branched-chain amino acid (BCAA) metabolism in regulating adiposity during systemic hypoxia. The research aims to elucidate the mechanisms underlying the reprogramming of BCAA metabolism in adipose tissue under oxygen deprivation, and to determine the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to determine the developmental origins and regulation of dermal adipose tissue. The $121,875 award, granted on April 5, 2025, will be performed by the University of Pennsylvania and aims to: (1) elucidate the mechanisms by which the transcription factor BCL11B...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to evaluate the therapeutic potential of a new orally active small molecule in obesity-linked diabetic models. The $418,560 award, effective September 1, 2024 through April 30, 2025, supports research to: 1) analyze the pharmacokinetic profiles of a new small molecule, 2) investigate the efficacy and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $245,123 to support research on the role of vascular sympathetic neurons in brown adipose tissue and their impact on systemic metabolism. The project, led by The Trustees of Columbia University in the City of New York, aims to use novel genetic and chemogenetic tools, advanced...