This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the pathophysiological mechanisms of the brain's endogenous glucagon-like peptide 1 (GLP-1) system and its role in diet-induced obesity. The total award amount is $655,971.00, with a project period from August 5, 2024, to June 30, 2029. The primary objectives of this...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $222,500 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Beckman Research Institute of the City of Hope. The grant supports research to understand how conjugated bile acids regulate metabolism after bariatric surgery, with the goal of developing safer and more affordable treatments for obesity and associated fatty liver diseases. The key objectives are: 1)...
This federal Project Grant award of $107,987 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a 5-year clinical training course at the Pennington Biomedical Research Center in Baton Rouge, Louisiana. The course, titled "Clinical Methods for Nutrition and Obesity Research," will provide hands-on training in state-of-the-art clinical research...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will provide $340,175 to American University to conduct research on the effects of federal funding for obesity prevention programs on weight-related health behaviors, obesity prevalence, and obesity-related chronic health conditions. The study will leverage variation in which counties and...
This federal Project Grant award of $410,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to investigate the role of dorsal medial hypothalamus (DMH) neurons in mediating the effects of glucagon-like peptide-1 (GLP-1) on neuropeptide Y/agouti-related peptide (NPY/AGRP) neuron activity and metabolism. The research, conducted by The University of Texas Southwestern...
This $502,233 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to identify and understand neuron populations in the brainstem that mediate the aversive and non-aversive suppression of food intake. The research, conducted by the Regents of the University of Michigan, aims to define neuron populations in the nucleus of the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the relationship between obesity, microglia activation, and perineuronal nets (PNNs) in the hypothalamus. The $176,500 award will fund studies to quantify the role of microglia in regulating ARC PNN turnover, determine if diet-induced obesity (DIO)-induced loss of...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $645,574 to Syntis Bio Inc. to develop an oral pill that mimics the effects of gastric bypass surgery. The goal is to create a once-daily oral medication that can block nutrient absorption in the duodenum, thereby replicating the weight loss benefits of Roux-en-Y gastric bypass surgery...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $364,125 to Emory University to determine how obesity alters the function and distribution of gastric endocrine progenitor cells. The research aims to directly test whether activation of Notch signaling contributes to the metabolic dysregulation and altered function of gastric endocrine...
This federal Project Grant award of $123,908.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, supports research to investigate the role of the ANO4 chloride channel in the area postrema (AP) of the brain and its impact on obesity and glucose homeostasis. The primary objectives are to: 1) examine how loss of ANO4 function in the AP affects metabolic phenotypes in...