This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a $389,578 multi-center clinical research project focused on improving the treatment of achalasia, a rare esophageal motility disorder. The project, titled "Precision Medicine in Achalasia - PREMEDIA", aims to test an innovative, tailored approach to per-oral endoscopic...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $594,956 to the University of South Florida to conduct research on the mechanisms underlying stretch-evoked activation of esophageal vagal afferents. The goal is to determine the mechanosensitive channels and sodium channels responsible for transducing esophageal stretch into vagal afferent...
This federal Project Grant award of $301,840 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports a research project titled "EPIC-LT: ELIMINATING PGD THROUGH INHIBITION OF CCR5 IN LUNG TRANSPLANTATION". The primary objectives are to: Measure the feasibility of recruiting lung transplant recipients for a pilot clinical trial of CCR5 inhibition to prevent primary graft dysfunction (PGD). Assess the safety and tolerability of the...
This Project Grant award of $964,718 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research will fund research at Northwestern University to develop and validate a "Virtual Esophagus" (VESOPHAGUS) simulation model. The goal is to leverage this model to define the physiomechanical factors driving poor outcomes in patients with achalasia and gastroesophageal reflux disease (GERD),...
This $475,605 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to definitively evaluate gastric dysrhythmia as a disease mechanism underlying functional dyspepsia and chronic nausea/vomiting syndromes, which affect over 10% of the population. The project will apply a novel non-invasive diagnostic approach called Body...
The University of California, San Diego (UCSD) was awarded a $1,580,000 Project Grant from the Defense Health Agency's Military Medical Research and Development (CFDA 12.420) program. The grant, effective March 1, 2025 through February 29, 2028, will support "MULTIOMIC APPROACHES FOR NONINVASIVE PREDICTION OF INFLAMMATORY BOWEL DISEASE EXACERBATIONS." This research aims to transform healthcare for military service members, veterans, and the broader public through innovative...
This Project Grant award for $656,000.00, provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program, supports advanced biomedical research on the progression of Barrett's esophagus to invasive esophageal adenocarcinoma. The research, conducted by The Regents of the University of California, San Francisco (UCSF), will investigate the role of myeloid cells and other inflammatory components in this disease progression. The award period runs from...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $632,204 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Mayo Clinic to conduct a pilot, randomized, double-blind, placebo-controlled clinical trial. The trial will investigate the efficacy and safety of proteolytic activity-guided fecal microbiota transplantation (FMT) for treating irritable bowel syndrome (IBS), specifically the post-infection IBS...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $850,232 to Northwestern University to advance the evolution of the Chicago Classification for diagnosing esophageal motor disorders. The project aims to develop new approaches combining assessments of esophageal neuromyogenic function and geometry to identify biomechanical physiomarkers of...
This $664,744 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), will fund a randomized Phase I/II pilot clinical trial to evaluate the safety, tolerability, feasibility, and efficacy of phage therapy for reducing recurrent urinary tract infections (rUTIs) in female kidney transplant recipients. The trial will compare phage therapy targeting E. coli and...