This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate survivorship trajectories and clinical outcomes for liver transplant recipients. The $365,378 award will fund a 5-year study to: 1) characterize distinct post-liver transplant survivorship phenotypes, 2) examine the relationship between survivorship phenotypes and outcomes like medication adherence...
The University of Louisville, through its Office of Research & Innovation Division, received a $464,073 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to develop a generative AI-based system for accurate prediction of deceased donor liver-transplant (DDLT) outcomes and viability. The proposed system will use deep learning techniques to produce "virtual" Masson's trichrome stained slides from input hematoxylin and eosin...
This $1,470,094 project grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research by New York University School of Medicine to optimize pre-implantation kidney transplant biopsy interpretation using artificial intelligence (AI) assistance. The key products and services to be delivered under this 5-year project include: Developing a comprehensive unbiased atlas of histopathology in pre-implantation deceased donor kidney biopsies using...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $385,250 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Florida for a research project titled "Liquid Biopsy Technology Towards Individualized Immunosuppression Therapy". The project aims to use extracellular vesicles (EVs) derived from the liver and gut as biomarkers to assess CYP3A4/5 expression and inform precise dosing of the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support the development of a proteomic assay to monitor the success of regenerative medicine therapies involving cell replacement and artificial tissues, such as liver disease treatments. The $175,964 award to Hepatx Corporation will enable the creation of a simple blood test to measure the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $664,769 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Oregon Health & Science University (OHSU). The grant, awarded on July 1, 2025, supports research to overcome barriers to therapeutic hepatocyte transplantation. Specifically, the project aims to genetically enhance donor hepatocytes to make them immune stealthy and expandable, enabling...
This Project Grant award of $3,740,270, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development and evaluation of a subnormothermic (room temperature) oxygenated perfusion platform for extended preservation of high-risk kidney grafts. The awardee, Biomedinnovations, Inc. (BMI), is collaborating with investigators at the Duke Ex Vivo Organ Lab...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at Georgetown University to establish cell type-specific biomarkers derived from cell-free methylated DNA (cfDNA) as novel viability parameters for assessing the quality and viability of donor livers during normothermic machine perfusion (NMP). The $429,000 grant, awarded from July 1, 2025 to June 30,...
This Project Grant award of $380,625 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate how the heme metabolite unconjugated bilirubin regulates liver and kidney function in primary human cells and organoids. The research aims to: 1) determine how toxic and beneficial levels of bilirubin are sensed in primary human hepatocytes and kidney...
This Project Grant award of $1,508,800.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by The University of Texas Southwestern Medical Center (UT Southwestern) to elucidate the role of somatic genetics in chronic liver disease pathways. The research aims to 1) identify adaptive genetic pathways specific to liver disease etiologies,...