The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $664,769 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Oregon Health & Science University (OHSU). The grant, awarded on July 1, 2025, supports research to overcome barriers to therapeutic hepatocyte transplantation. Specifically, the project aims to genetically enhance donor hepatocytes to make them immune stealthy and expandable, enabling...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $199,999 to the University of Florida to develop innovative artificial intelligence (AI)-based methods to support the discovery of potent, orally available small-molecule heparanase inhibitors. The goal is to evaluate these novel heparanase inhibitors in murine models as a...
This $391,250 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research on extracellular vesicle-dependent RNA signaling in metabolism. The project aims to identify key proteins involved in the delivery of adipose microRNAs into liver cells via extracellular vesicles, and to determine if this RNA delivery mechanism is necessary for...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $748,049.00 to Rutgers, The State University of New Jersey, to conduct a multi-center validation and biological assessment of a novel pre-transplant biomarker panel to predict liver transplant recipient mortality. The project aims to advance the Liver Immune Frailty Index (LIFI) as an...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $243,750 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of the University of Pennsylvania. The grant will fund the development of novel methods to improve detection of mosaic chromosomal alterations (MCA) in non-neoplastic tissues like the kidney and blood. The project aims to create single-cell sequencing techniques and spatial...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $1,091,998.00 to Duke University to conduct research on the role of monocytes and macrophages in kidney transplantation. The key objectives are to: (1) Determine the mechanisms by which the receptor tyrosine kinase AXL influences early post-transplant monocyte differentiation and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $296,022 to the University of Florida to study changes in central carbon and lipid metabolism in the exocrine pancreas in type 1 diabetes. The research aims to quantify alterations in exocrine pancreatic central carbon metabolism and determine rates of lipid turnover, using a...
This $1,470,094 project grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research by New York University School of Medicine to optimize pre-implantation kidney transplant biopsy interpretation using artificial intelligence (AI) assistance. The key products and services to be delivered under this 5-year project include: Developing a comprehensive unbiased atlas of histopathology in pre-implantation deceased donor kidney biopsies using...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $436,277 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS" aims to develop an easy-to-use 3D in vitro model of the developing nephron that allows spatial patterning...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Vanderbilt University Medical Center (VUMC) a $150,000 Project Grant under CFDA 93.847, the Diabetes, Digestive, and Kidney Diseases Extramural Research program. The grant, which runs from Sep 1, 2023 to Aug 31, 2024, will fund a study to identify factors that contribute to clonal expansion and disease progression in clonal hematopoiesis of indeterminate potential (CHIP). The research aims to dissect the...