This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $175,964 to Hepatx Corporation to develop a proteomic assay for monitoring transplanted cells and tissues. The goal is to create a simple blood test that can detect differences in amino acid sequences of donor hepatocyte proteins compared to recipient proteins, enabling the assessment of the success of cell...
This $754,400 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The funding will support research by The University of Texas Southwestern Medical Center (UT Southwestern) to identify adaptive genetic pathways and understand how mutant clones expand within chronically damaged liver tissues, with the goal of developing therapeutic approaches...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,558,188 supports research to investigate how changes in transcription factor and heterochromatin states impact hepatocyte development, homeostasis, and regeneration in mouse embryos and adult livers. The research, led by investigators at the University of Pennsylvania and Children's Hospital of Philadelphia,...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research), aims to characterize survivorship phenotypes and outcomes of liver transplant recipients. The PI will use longitudinal monitoring of patient-reported and clinical data to identify at-risk survivors who may benefit from a navigator-based intervention. The $365,378 award, effective from March 3, 2025 through...
This $806,452 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research investigating the mechanisms that combine type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). The research aims to determine how hepatic insulin resistance can lead to the progression of NAFLD to the more severe non-alcoholic steatohepatitis (NASH), and how this...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $385,250 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the University of Florida for a research project titled "Liquid Biopsy Technology Towards Individualized Immunosuppression Therapy". The goal is to use liver-derived extracellular vesicles as biomarkers to predict variability in tacrolimus pharmacokinetics and optimize dosing in liver transplant...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to define the role of antigen-specific T cell responses in the progression of non-alcoholic steatohepatitis (NASH), a chronic liver disease. The $599,541 award, with a project period from September 2024 to August 2025, will fund research at the University of Colorado-Denver to investigate:...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $272,964 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The award, effective August 1, 2024 through May 31, 2026, will support research to investigate the role of SMAD1/5/8 signaling in hepatocytes and hepatic stellate cells (HSCs) in liver fibrosis. The...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $234,735 to The Regents of the University of California, San Francisco (UCSF) to conduct research on improving immune responses against hepatitis B virus (HBV) infection. The research aims to investigate the mechanisms behind age-related differences in the body's ability to clear HBV surface antigen, which...
This $148,568 Project Grant was awarded on January 9, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by The Leland Stanford Junior University to: 1) Optimize a low-intensity conditioning protocol to generate stable mixed hematopoietic chimerism and induce donor-specific tolerance for allogeneic islet transplantation, and 2)...