Project Grant R21AI191090

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $429K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Washington, DC, USA
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This federal Project Grant award of $433,125.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research conducted by the University of California, Los Angeles (UCLA) to investigate the role of TIM-4 signaling in nonalcoholic steatohepatitis (NASH) liver transplant ischemia/reperfusion injury. The research aims to determine if TIM-4-derived foamy macrophages in NASH liver grafts are a risk factor for primary graft...
The U.S. National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1.2M Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to the Terasaki Institute For Biomedical Innovation. The objective of this 4-year project is to develop and validate a multi-organ-on-a-chip (MOC) platform comprised of vascularized liver and heart models to study the underlying mechanisms of antibody-mediated rejection (ABMR) in organ transplantation. The platform will...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $748,049.00 to Rutgers, The State University of New Jersey, to conduct a multi-center validation and biological assessment of a novel pre-transplant biomarker panel to predict liver transplant recipient mortality. The project aims to advance the Liver Immune Frailty Index (LIFI) as an...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support the development of a proteomic assay to monitor the success of regenerative medicine therapies involving cell replacement and artificial tissues, such as liver disease treatments. The $175,964 award to Hepatx Corporation will enable the creation of a simple blood test to measure the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,135,986 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Northwestern University to investigate strategies for mitigating cytomegalovirus (CMV) reactivation in kidney transplant recipients. The research aims to identify cellular and molecular targets, specifically related to endoplasmic reticulum stress and mitochondrial dysfunction in renal endothelial cells, that can be...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research grant program (CFDA 93.855) will support research to identify immune signatures that predict the risk of cytomegalovirus (CMV) disease in liver transplant recipients. The $832,910 award to the University of Washington will fund a 5-year study to characterize the humoral and cellular immune responses to CMV, including neutralizing antibodies and the...
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The federal Project Grant award R01AI180237, totaling $1,286,273.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award aims to develop clinically applicable protocols for inducing tolerance in liver transplant recipients and define the mechanisms of liver transplant tolerance. The research will test strategies to promote durable donor mixed chimerism, which is hypothesized to...
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This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at Georgetown University to establish cell type-specific biomarkers derived from cell-free methylated DNA (cfDNA) as novel viability parameters for assessing the quality and viability of donor livers during normothermic machine perfusion (NMP). The $429,000 grant, awarded from July 1, 2025 to June 30, 2027, aims to: 1) establish cfDNA-derived cell type-specific injury markers as novel biomarkers for determining organ viability at the time of machine perfusion, and 2) establish cfDNA-derived cell type-specific injury markers as novel biomarkers for determining the nature and severity of complications post-transplant. This research could help expand the number of viable livers available for transplant, enhance monitoring of transplanted livers, and inform therapeutic strategies to improve outcomes for liver transplant patients.

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