Project Grant R01DE035445
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $429,000 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of autophagy in enamel development and amelogenesis imperfecta. The research addresses amelogenesis imperfecta, a congenital tooth enamel defect characterized by abnormally thin, soft, fragile, and discolored enamel that causes social embarrassment, dental pain,...
- The National Institute of Dental and Craniofacial Research awarded Regents of the University of Michigan $312,000 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate retinoic acid signaling in ameloblast differentiation during dental enamel formation. The research integrates single-cell RNA-sequencing data from 14 studies across mouse, rat, and human tooth development to determine ameloblast differentiation trajectories and elucidate the role...
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of California, San Francisco $693,185 on June 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate mechanistic insights into amelogenin alternative splicing and its regulatory roles in amelogenesis imperfecta. The research examines how the amelogenin gene undergoes alternative splicing to produce distinct protein versions and regulatory molecules, with...
- The National Institute of Dental and Craniofacial Research awarded the University of Pittsburgh $683,474 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to unravel the molecular basis of tooth agenesis through large-scale genetic discovery and functional characterization. The project will conduct whole-exome and whole-genome sequencing in approximately 450 individuals from a well-characterized tooth agenesis dataset to identify rare variants and test...
- The National Institute of Dental and Craniofacial Research awarded the University of Maryland, Baltimore $311,000 on June 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate citrate regulation mechanisms in tooth enamel development. The research examines how solute carrier family 13 member 5 (SLC13A5) and progressive ankylosis protein (ANK) regulate amelogenesis through citrate signaling pathways. The study employs histological analysis, microCT imaging,...
- The National Institute of Dental and Craniofacial Research, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $600,214 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to define the neuronal basis of odontogenic pain and identify targets for non-opioid analgesic development. The project, led by Dr. Joshua Emrick, investigates the cells, circuits, and behavioral...
- The National Institute of Dental and Craniofacial Research awarded Northwestern University $633,074 under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 1, 2026, to conduct multiscale modeling of enamel dissolution in caries formation. The research addresses how compositional gradients and residual stresses in tooth enamel crystallites influence the dissolution process during caries lesion formation. The project examines the core-shell structure of enamel crystallites,...
- The National Institute of Dental and Craniofacial Research awarded $593,876 to the Regents of the University of Michigan on August 7, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the molecular mechanisms regulating peritubular dentin mineralization and develop bioengineered strategies for targeted dentin reconstruction. The research uses six mouse models with varied amounts of dentin sialoprotein (DSP), dentin phosphoprotein (DPP), and chondroitin...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $710,519 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish a comprehensive, web-based developmental monitoring system for infants and toddlers with orofacial clefts. The project will track developmental status and trajectories across multiple domains—social/communication/cognition skills, motor abilities, early relational health, sleep,...
- The National Institute of Dental and Craniofacial Research awarded the University of California, Los Angeles $449,886 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research on the regulation of early mandibular morphogenesis by the homeobox protein MSX1. The research addresses craniofacial anomalies, which are among the most common congenital conditions. Mutations in the MSX1 gene are associated with tooth agenesis, cleft palate, and...
The National Institute of Dental and Craniofacial Research awarded Regents of the University of Michigan $442,870 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct genetic research on hereditary enamel defects. The project, titled "Discovery, Validation, and Mitigation of Genetic Mutations Underlying Hereditary Enamel Defects," integrates developmental and intervention genetics to advance knowledge and identify therapeutic premises for inherited tooth enamel disorders. Hereditary enamel defects, including amelogenesis imperfecta, occur at a prevalence of 1 in 700 to 14,000 and cause chronic pain, hypersensitivity, compromised digestive function, and psychological impairment in affected individuals. The research addresses the challenge that more than 115 genes and conditions exhibit enamel defects across 14 identifiable subtypes, creating complexity in genetic classification and clinical diagnosis. The project aims to establish accurate clinical and genetic diagnosis protocols to clarify pathogenicity, disease progression, and optimal management of systemic manifestations. The research leverages advanced genomic technologies, engineered delivery strategies, and well-characterized mutant mouse models. Work is performed at the University of Michigan in Ann Arbor, Michigan. The project period runs from August 1, 2026, through June 30, 2031. This is a Project Grant, a form of assistance funding supporting basic, translational, and clinical research in dental, oral, and craniofacial health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.9k | 8/3/26 |