The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $385,161 project grant on Sep 5, 2024 under the Oral Diseases and Disorders Research (CFDA 93.121) program to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) Division. This grant aims to investigate the role of p21 positive senescent cells in obesity, aging, and trauma-induced temporomandibular joint (TMJ) degeneration, a painful and debilitating joint disease...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $738,929 to The Trustees of Columbia University in the City of New York to develop and validate a patient-specific TMJ-on-a-chip (TMJOC) model. The TMJOC will be used to investigate multi-tissue crosstalk regulating temporomandibular joint (TMJ) disc injury and healing under inflammation and pathophysiological...
The federal Cooperative Agreement award UH3DE032204 was granted by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The $1,660,925.63 award supports a project at Thomas Jefferson University's Sidney Kimmel Medical College to utilize single-cell RNA sequencing to identify and classify cell populations and gene expression in temporomandibular joint (TMJ) synovial fluid from healthy and symptomatic TMJ...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $312,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Michigan Office of Research and Sponsored Projects to establish the Michigan Collaborative Hub for TMD Patient-Centric Research (MICH T PCR). The goal of the award is to transform the treatment of temporomandibular disorders (TMDs) through the translation of clinically-relevant innovations. The...
This federal Cooperative Agreement award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research grant program (CFDA 93.121), aims to conduct multi-omic investigations of temporomandibular joint (TMJ) disorders. The $587,428 award will support a two-phase project at the University of California, Los Angeles (UCLA) to: 1) develop protocols and infrastructure for data management, subject recruitment, and sample collection; and 2)...
This Cooperative Agreement award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a $1,207,004 clinical trial to evaluate the safety and analgesic efficacy of a marine oil supplement in adults with chronic temporomandibular disorder (TMD) pain. The study aims to determine if the supplement, which contains precursors to specialized pro-resolving mediators, can reduce pain intensity,...
This $222,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research at The Children's Hospital of Philadelphia (CHOP) to investigate the pathogenic mechanisms of temporomandibular joint (TMJ) osteophyte formation. The key objectives are to test whether conditional ablation of the gene EXT1, which is involved in heparan sulfate synthesis, causes osteophyte formation...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $168,228 to Rutgers, The State University of New Jersey to conduct a randomized, placebo-controlled clinical trial on the use of a novel temporo-masseteric nerve block (TMNB) injection to reduce post-surgical pain and improve jaw function following impacted wisdom tooth extractions. The study aims to evaluate the...
This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,702,003.00 to develop and assess the clinical potential of quantitative imaging biomarkers for evaluating changes in myofiber microstructure associated with masticatory myofascial pain syndrome (MMPS). The key products and services to be delivered include: 1) Establishing an optimal 15-minute MRI protocol and...