Project Grant R01DE035179
- This $162,743 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will support research at New York University (NYU) to study the role of Schwann cells in oral cancer pain mechanisms. The key objectives are to: 1) Develop and validate assays to measure pressure and stretch sensitivity in oral cancer, providing new methods to evaluate dimensions of oral cancer pain; 2)...
- This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of the truncated TRKB isoform in oral cancer pain. The $654,733 grant, awarded on August 13, 2025, will fund a project by the University of Texas Health Science Center at San Antonio to: Examine the contribution of the truncated TRKBT1 isoform in trigeminal sensory neurons and its...
- This federal Project Grant award of $248,999.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research aimed at elucidating the underlying mechanisms of motor cortex stimulation (MCS) as a non-opioid alternative for chronic pain management. The primary objectives are to: 1) characterize the efficacy and neurobiological mechanisms of somatotopically-matched MCS in a rodent model of trigeminal...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,764,145.00 to Midwestern University to conduct research on miRNA as a novel therapeutic target for pain management in sickle cell disease (SCD). The long-term goal is to develop effective pharmacological interventions to alleviate chronic pain and improve quality of life for SCD patients. The research focuses on...
- This federal Project Grant award for $1,587,553.00 was provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant is focused on developing novel 5-HT3 receptor antagonists for the treatment of neuropathic pain. The key objectives are to: 1) use computational drug design approaches to identify novel 5-HT3 receptor antagonist chemotypes with potential for central nervous system (CNS) penetration and...
- This $2,569,851 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate how the PD-L1/PD-1 immune checkpoint pathway controls physiological and pathological pain, as well as opioid analgesia, through neuronal, immune, and glial mechanisms. The project aims to validate the actions of PD-L1 and the checkpoint inhibitor nivolumab on neuroinflammation and...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- This federal Project Grant award in the amount of $5,057,591 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a comprehensive, prospective observational study with 2,400 emergency department patients seeking care for acute pain. The study aims to: 1) characterize clinically-informed pain phenotypes, 2)...
- This $672,660 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to elucidate the role of the fibronectin protein and its alternatively spliced variant (FN EDA) in mediating oral cancer-related pain. The project aims to (1) characterize the clinical profile of FN1 and FN EDA in metastasis-associated pain, (2) evaluate FN EDA's function within the nociceptive...
This $3,892,145 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funding research under the NIH Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of succinate signaling for pain relief in oral cancer. The primary objective is to determine if inhibiting the succinate receptor SUCNR1 can alleviate oral cancer pain by reducing inflammation and nociception (pain perception). The research involves using clinical samples, mouse models, and human tissue to study the distribution and neuromodulatory function of SUCNR1 in oral cancer. A novel SUCNR1 antagonist developed by the researchers will also be evaluated for its analgesic effects in an oral cancer mouse model. The project aims to provide new insights into leveraging the succinate/SUCNR1 signaling pathway as a potential therapeutic target for improved pain management in oral cancer patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.9m | 8/27/25 |