Project Grant R00DE031802
- This federal Project Grant award of $239,405.00, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the neural circuit mechanisms of peripheral nerve stimulation for the treatment of trigeminal neuropathic pain. The research aims to elucidate how peripheral nerve stimulation activates the thalamic reticular nucleus, a key brain region involved in regulating...
- This $162,743 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will support research at New York University (NYU) to study the role of Schwann cells in oral cancer pain mechanisms. The key objectives are to: 1) Develop and validate assays to measure pressure and stretch sensitivity in oral cancer, providing new methods to evaluate dimensions of oral cancer pain; 2)...
- This Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $226,530 award will support a research project at the University of California, San Francisco (UCSF) focused on using brain stimulation to identify and test network biomarkers for chronic pain relief. The project aims to leverage advanced functional MRI,...
- This federal Project Grant award for $667,349.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The award is supporting research conducted by the University of Pennsylvania to investigate the role of endogenous opioid signaling and neural circuits involved in modulating pain perception and placebo analgesia. The research aims to elucidate the...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- This $341,958 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the regulation of nociceptor excitability by Macrophage Migration Inhibitory Factor (MIF) as a potential therapeutic strategy for treating chronic neuropathic pain after spinal cord injury (SCI). The 5-year research project, awarded to the University of Texas Health Science...
- This $3,892,145 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funding research under the NIH Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of succinate signaling for pain relief in oral cancer. The primary objective is to determine if inhibiting the succinate receptor SUCNR1 can alleviate oral cancer pain by reducing inflammation and nociception (pain...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,702,003.00 to develop and assess the clinical potential of quantitative imaging biomarkers for evaluating changes in myofiber microstructure associated with masticatory myofascial pain syndrome (MMPS). The key products and services to be delivered include: 1) Establishing an optimal 15-minute MRI protocol and...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $9,237,770 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University to conduct the "IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain After Surgery" research project. The goal is to gain integrated mechanistic insights into peripheral and central biological processes that contribute to chronic postsurgical pain...
- This $147,486 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Carnegie Mellon University supports research to identify and target neural subpopulations in the spinal cord that mediate chronic pain. The project aims to analyze the genomic cis-regulatory elements (CREs) of neural subtypes in the macaque and mouse spinal cord to characterize the genetic markers...
This federal Project Grant award of $248,999.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research aimed at elucidating the underlying mechanisms of motor cortex stimulation (MCS) as a non-opioid alternative for chronic pain management. The primary objectives are to: 1) characterize the efficacy and neurobiological mechanisms of somatotopically-matched MCS in a rodent model of trigeminal neuropathic pain, 2) determine the specific opioid receptor subtypes required for MCS antinociception, and 3) identify how endogenous opioids modulate descending pain control pathways during MCS. The research will utilize behavioral paradigms, pharmacological interventions, and genetic mouse models to investigate these questions, with the goal of improving the clinical efficacy of MCS as a novel chronic pain treatment strategy. The award period runs from July 1, 2025 to June 30, 2028 and the research is being conducted by the Winifred Masterson Burke Medical Research Institute, Inc. in White Plains, NY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/4/25 |