Project Grant R01DE034087
- This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
- This $162,743 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will support research at New York University (NYU) to study the role of Schwann cells in oral cancer pain mechanisms. The key objectives are to: 1) Develop and validate assays to measure pressure and stretch sensitivity in oral cancer, providing new methods to evaluate dimensions of oral cancer pain; 2)...
- This Project Grant award of $315,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The goal of this 2-year project is to study the role of the TRPC1 protein as a potential therapeutic target for treating oral squamous cell carcinoma (OSCC), a common and deadly type of head and neck cancer. The research will focus on understanding how TRPC1 mediates calcium...
- This $672,660 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to elucidate the role of the fibronectin protein and its alternatively spliced variant (FN EDA) in mediating oral cancer-related pain. The project aims to (1) characterize the clinical profile of FN1 and FN EDA in metastasis-associated pain, (2) evaluate FN EDA's function within the nociceptive...
- This $3,892,145 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funding research under the NIH Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of succinate signaling for pain relief in oral cancer. The primary objective is to determine if inhibiting the succinate receptor SUCNR1 can alleviate oral cancer pain by reducing inflammation and nociception (pain...
- This $622,744 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The grant will fund research to investigate the role of the TRPM2 protein in the development of radiation-induced oral mucositis (RIOM), a common and painful side effect of radiation therapy for head and neck cancer. The research aims to understand how TRPM2 activation contributes to RIOM through the...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $511,578 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, awarded on August 21, 2025, will fund research to understand the role of bitter taste receptors (T2Rs) in oral cancer tumor-associated macrophages. The research aims to define the...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- This federal Project Grant award of $239,405.00, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the neural circuit mechanisms of peripheral nerve stimulation for the treatment of trigeminal neuropathic pain. The research aims to elucidate how peripheral nerve stimulation activates the thalamic reticular nucleus, a key brain region involved in regulating...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of the truncated TRKB isoform in oral cancer pain. The $654,733 grant, awarded on August 13, 2025, will fund a project by the University of Texas Health Science Center at San Antonio to: Examine the contribution of the truncated TRKBT1 isoform in trigeminal sensory neurons and its impact on pain behaviors, neuronal plasticity, and gene expression. Evaluate whether OSCC-derived TRKBT1 regulates pain-associated changes in the tumor microenvironment, including immune cell profiles, transcriptomic changes, and single-cell analysis in tongue tumors. The research aims to provide novel insights into truncated TRKBT1 biology, oral cancer pathophysiology, and cancer-induced pain, with the potential to identify new therapeutic approaches for treating oral tumorigenesis and pain.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $654.7k | 8/13/25 |