Project Grant RF1NS143697
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) aims to advance the understanding of the molecular and neurobiological mechanisms underlying chronic pain in sickle cell disease (SCD) and develop effective pharmacologic treatments. The $1,103,783 award to the University of Illinois will utilize well-characterized sickle cell transgenic mouse models to study epigenetic, neurobiology, and gut microbiota...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funded under the Drug Use and Addiction Research Programs (CFDA 93.279). The $1,098,640 grant, awarded on September 18, 2025, supports a longitudinal research project titled "Modeling Inter-Individual Differences to Address Pain of Sickle Cell Disease (MIDAS)" at the University of Texas at Arlington (UTA). The project aims to collect...
- This $1,049,682 federal Project Grant award from the National Institute of Neurological Disorders and Stroke, under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a 5-year prospective cohort study to develop and validate novel computational and clinical tools for understanding and addressing differences in pain experience and response to pain treatment among people with sickle cell disease (SCD). The study will utilize the Globin Research Network for Data and Discovery...
- This $4,039,366 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), will support a research project titled "A Fully Humanized Functional Genomic Screen to Identify and Validate Pain Therapeutic Targets" under the NIH's Drug Use and Addiction Research Programs (CFDA 93.279). The project will leverage innovative CRISPR-based screening and human dorsal root ganglion (DRG) transcriptomic data to...
- This $341,958 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the regulation of nociceptor excitability by Macrophage Migration Inhibitory Factor (MIF) as a potential therapeutic strategy for treating chronic neuropathic pain after spinal cord injury (SCI). The 5-year research project, awarded to the University of Texas Health Science...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $444,125 in funding to Duke University to explore the role of the LRRC55 regulatory protein in pain pathways. The key objectives are to: 1) delineate LRRC55's function in chronic pain behaviors using genetically-modified mice, 2) quantify changes in LRRC55 expression in dorsal root ganglion and spinal cord neurons...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), awarded a $1,955,201 Cooperative Agreement to Cincinnati Children's Hospital Medical Center under the NIH Drug Use and Addiction Research Programs (CFDA 93.279). The 5-year award, effective September 19, 2025 through July 31, 2030, will support research to better understand the biopsychosocial determinants of pediatric-onset chronic musculoskeletal pain. The research will...
- This $429,000 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of Schwann cell PIEZO1 in pain sensation. The key objectives are to: 1) develop and validate adeno-associated virus (AAV) vectors for selective inhibition of Schwann cell PIEZO1, and 2) determine the sensory effects of Schwann cell...
- This $147,486 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to Carnegie Mellon University supports research to identify and target neural subpopulations in the spinal cord that mediate chronic pain. The project aims to analyze the genomic cis-regulatory elements (CREs) of neural subtypes in the macaque and mouse spinal cord to characterize the genetic markers...
- This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,764,145.00 to Midwestern University to conduct research on miRNA as a novel therapeutic target for pain management in sickle cell disease (SCD). The long-term goal is to develop effective pharmacological interventions to alleviate chronic pain and improve quality of life for SCD patients. The research focuses on investigating the functional role of the let-7 miRNA family, which has been implicated in the onset of SCD pain. The award period is from August 1, 2025 to July 31, 2029. The project aims to generate preliminary data demonstrating that targeting let-7 miRNA can reverse persistent pain behaviors in a humanized mouse model of SCD, laying the groundwork for future translational research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.8m | 7/30/25 |