Project Grant R56DE033513
- This $162,743 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will support research at New York University (NYU) to study the role of Schwann cells in oral cancer pain mechanisms. The key objectives are to: 1) Develop and validate assays to measure pressure and stretch sensitivity in oral cancer, providing new methods to evaluate dimensions of oral cancer pain; 2)...
- This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of the truncated TRKB isoform in oral cancer pain. The $654,733 grant, awarded on August 13, 2025, will fund a project by the University of Texas Health Science Center at San Antonio to: Examine the contribution of the truncated TRKBT1 isoform in trigeminal sensory neurons and its...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $238,668 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Connecticut. The project aims to diagnose and differentiate dental pain from stress using a wearable electrodermal activity (EDA) device. Specifically, the project will leverage skin nerve activity (SKNA) signals derived from electrocardiograms to precisely identify the onset and end of...
- This $3,892,145 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funding research under the NIH Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of succinate signaling for pain relief in oral cancer. The primary objective is to determine if inhibiting the succinate receptor SUCNR1 can alleviate oral cancer pain by reducing inflammation and nociception (pain...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $511,578 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, awarded on August 21, 2025, will fund research to understand the role of bitter taste receptors (T2Rs) in oral cancer tumor-associated macrophages. The research aims to define the...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- This Project Grant award of $315,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The goal of this 2-year project is to study the role of the TRPC1 protein as a potential therapeutic target for treating oral squamous cell carcinoma (OSCC), a common and deadly type of head and neck cancer. The research will focus on understanding how TRPC1 mediates calcium...
- This federal Project Grant award of $248,999.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research aimed at elucidating the underlying mechanisms of motor cortex stimulation (MCS) as a non-opioid alternative for chronic pain management. The primary objectives are to: 1) characterize the efficacy and neurobiological mechanisms of somatotopically-matched MCS in a rodent model of trigeminal...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
This $672,660 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to elucidate the role of the fibronectin protein and its alternatively spliced variant (FN EDA) in mediating oral cancer-related pain. The project aims to (1) characterize the clinical profile of FN1 and FN EDA in metastasis-associated pain, (2) evaluate FN EDA's function within the nociceptive cascade, and (3) investigate FN EDA's ability to sensitize the TRPV1 pain receptor. The goal is to identify new targets within the oral cancer microenvironment that can be leveraged to alleviate pain in oral cancer patients, independent of opioid-based therapies. The award period runs from August 2025 to August 2027 and is being conducted by New York University, a prominent private research institution with an extensive federal research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $672.7k | 8/21/25 |