Project Grant R01DE034757
- This federal Project Grant award of $645,009 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the role of osteocytes and the NOD1 receptor in the mechanism of alveolar bone loss associated with periodontal disease. The research aims to improve understanding of how bacteria interact with osteocytes via NOD1 signaling, leading to increased RANKL expression and subsequent...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of the nucleotide-metabolizing enzyme CD73 in the pathogenesis of periodontal disease. The $762,432 award to Augusta University Research Institute, Inc. will fund a 5-year project to delineate how CD73 deficiency leads to metabolic dysfunction and heightened inflammation in...
- This $588,952 federal Project Grant was awarded on April 18, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports the development of a bio-inspired "PerioPatch" scaffold to regenerate Sharpey's fibers and the periodontal ligament, which are critical components of the periodontal tissue structure that are often...
- The U.S. National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant on May 1, 2025 to The Medical University of South Carolina under the Oral Diseases and Disorders Research (CFDA 93.121) program. The goal of this 2-year project is to define how oral pathogens affect aging-associated immune responses and whether inhibition of the CD38 signaling pathway can attenuate inflammatory bone loss and alleviate aging-related immune responses induced by oral...
- This $185,918 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will fund research to evaluate the impact of Medicaid coverage for treatment of periodontal disease on health outcomes. The primary objectives are to assess the effect of this Medicaid coverage on outcomes such as tooth loss, emergency department use for dental problems, and oral healthcare costs. The...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $309,038 Project Grant to Virtici LLC, a for-profit biomedical research and development company based in Seattle, Washington. The purpose of this grant is to develop a novel inhibitor targeting the "red complex" bacteria P. gingivalis, T. forsythia, and T. denticola, which are considered the causative agents of...
- This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports scientific research on Porphyromonas gingivalis, a key pathogen in periodontal disease. The $358,823 award to Loma Linda University aims to expand the understanding of the biogenesis and localization of gingipains, which are virulence factors essential for the bacterium's pathogenicity. The research focuses...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, is funded under the Oral Diseases and Disorders Research (CFDA 93.121) program. The $557,606 grant will support research at Harvard Medical School to advance the understanding of periodontal stem cell populations and their regulation for periodontal tissue regeneration. The research aims to elucidate fundamental questions about distinct...
- The University of Washington was awarded a $311,000 project grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The grant will fund a 2-year research project to characterize the microbial and inflammatory state within clinically healthy tissues of patients with active periodontal disease, using single-cell RNA sequencing (scRNA-seq) techniques. The goal is to improve understanding of how...
- This $913,000 project grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on research into periodontal regeneration using supramolecular nanomaterials. The primary awardee, the University of Southern California (USC), is conducting research to identify bioactive peptides from the commercial product Emdogain that can stimulate the differentiation of periodontal ligament cells...
This federal Project Grant award of $385,116.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research to investigate the role of senescent cells in the periodontal ligament as a potential therapeutic target for age-associated periodontitis, a leading cause of tooth loss in adults. The research is being conducted by the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) in Augusta, GA. The project aims to determine if removing senescent cells in the periodontal ligament can prevent age-related bone loss associated with periodontal disease. This research seeks to develop new therapeutic approaches to address the growing socioeconomic burden of periodontal disease, which cost $3.49B in the U.S. in 2018. The award period runs from August 2025 through May 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $385.1k | 8/22/25 |