Project Grant R01DE034386
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $427,208 to Virginia Commonwealth University (VCU) to evaluate the immunotherapeutic activity and mechanism of action of a novel immune prime agent, called hFLAGRP170, in enhancing head and neck cancer responsiveness to standard treatments like radiation therapy and immune checkpoint inhibitors. The research aims to...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $716,123 Project Grant to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Florida. The grant, awarded on September 8, 2025, aims to establish a clinical cohort and develop novel analytical methodologies to validate, discover, and optimize non-invasive liquid biopsy tests for prognosis prediction in head and...
- This federal Project Grant award of $1,899,042.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research at the University of Pittsburgh to analyze high-dimensional genomic datasets to reveal mechanistic insights on divergent outcomes of head and neck cancer. The project aims to use existing public databases of human head and neck squamous cell carcinomas (HNSCC) to identify new mechanisms...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- This $642,488 Project Grant was awarded on June 10, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the federal Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research conducted by a collaborative partnership between Henry Ford Health and Michigan State University Health Sciences to investigate mechanisms by which human papillomavirus (HPV) drives immune evasion in head and neck squamous cell carcinomas (HNSCC). The research aims...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $129,289 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Leland Stanford Junior University. The grant funds research to develop lysosome-targeting chimeras (LYTACs) that can degrade immune checkpoint proteins and enhance immunoradiotherapy for head and neck cancer. The project aims to evaluate the impact of LYTACs on immune cell modulation and their therapeutic potential in...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $219,660 Project Grant to the Regents of the University of Michigan to conduct research on "Intercepting the Evolution of Pro-Tumoral Myeloid Cells During the Initiation of Oral Cancer". This project aims to investigate how myeloid cells in precancerous lesions develop suppressive phenotypes that inhibit anti-tumor immune...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $156,000 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Colorado-Denver. The grant will support a research project titled "Sex-Specific Immune Microenvironment in Oral Cancer" from July 1, 2025 to June 30, 2027. The research aims to investigate sex-specific differences in the immune microenvironment of head and neck squamous cell...
- The Project Grant award titled "DECIPHERING THE MECHANISM OF RESPONSE TO NOVEL HPV-SPECIFIC VIRAL IMMUNE THERAPY IN HPV ASSOCIATED HEAD AND NECK CANCER" was provided by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The $451,000 award supports research conducted by the University of Chicago to develop and evaluate a novel immunotherapy platform called HB-200, which uses attenuated...
- The Project Grant award titled "UNDERSTANDING THE MECHANISMS BEHIND RADIOTHERAPY RESISTANCE OF IMMUNOLOGICALLY COLD HEAD AND NECK CANCER" was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The $320,000 award will support research conducted by Baylor College of Medicine to develop a novel genetically engineered mouse model (GEMM) to study the role of the KEAP1/NRF2...
This federal Project Grant award of $3,742,682 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Dana-Farber Cancer Institute, Inc. (DFCI) in Massachusetts. The grant supports research to dissect the role of the chemokine CCL5 in shaping antigen-specific T cell responses against head and neck cancers. Key objectives include: The award period runs from August 21, 2025 to August 20, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.7m | 8/21/25 |