Project Grant K99DE034475
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $308,223 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Leland Stanford Junior University (Stanford University). The grant, awarded on July 15, 2025, supports research to define how the gene ACTL6A contributes to metabolic reprogramming in head and neck squamous cell carcinoma (HNSCC). The research aims to quantify energy production in HNSCC cells with varying ACTL6A levels,...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $427,208 to Virginia Commonwealth University (VCU) to evaluate the immunotherapeutic activity and mechanism of action of a novel immune prime agent, called hFLAGRP170, in enhancing head and neck cancer responsiveness to standard treatments like radiation therapy and immune checkpoint inhibitors. The research aims to...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- This federal Project Grant award of $3,742,682 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Dana-Farber Cancer Institute, Inc. (DFCI) in Massachusetts. The grant supports research to dissect the role of the chemokine CCL5 in shaping antigen-specific T cell responses against head and neck cancers. Key objectives include: Investigating how CCL5 chemokine networks impact the development...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $716,123 Project Grant to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Florida. The grant, awarded on September 8, 2025, aims to establish a clinical cohort and develop novel analytical methodologies to validate, discover, and optimize non-invasive liquid biopsy tests for prognosis prediction in head and...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $298,942 Project Grant to Deltamed LLC on August 20, 2025. The grant funding will support the development of a novel "nanosponge prodrug delivery system" for the small molecule MK2 inhibitors apatinib and MMI-0100. The goal is to improve the circulation half-life and targeted delivery of these compounds to mitigate...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,465,026 Project Grant on April 8, 2025 under the Oral Diseases and Disorders Research program (CFDA 93.121) to The University of Texas M.D. Anderson Cancer Center. The grant, titled "Harvard MD Anderson Collaborative to Reduce Lymphatic Morbidity in Head and Neck Cancer with Artificial Intelligence (HARMONIC-AI)," aims to leverage computational imaging and AI to enhance the detection and management of...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $511,578 Project Grant under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, awarded on August 21, 2025, will fund research to understand the role of bitter taste receptors (T2Rs) in oral cancer tumor-associated macrophages. The research aims to define the...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $156,000 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Colorado-Denver. The grant will support a research project titled "Sex-Specific Immune Microenvironment in Oral Cancer" from July 1, 2025 to June 30, 2027. The research aims to investigate sex-specific differences in the immune microenvironment of head and neck squamous cell...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $129,289 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Leland Stanford Junior University. The grant funds research to develop lysosome-targeting chimeras (LYTACs) that can degrade immune checkpoint proteins and enhance immunoradiotherapy for head and neck cancer. The project aims to evaluate the impact of LYTACs on immune cell modulation and their therapeutic potential in preclinical animal models. This work builds on the university's previous research confirming the superior efficacy of eliminating immunosuppressive proteins compared to conventional blockade approaches for treating head and neck cancer. The award has a performance period from August 2, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $129.3k | 8/2/25 |