This $234,000 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to define the functional roles and mechanisms of the human microbiome in oral squamous cell carcinoma (OSCC). The award to the University of Colorado-Denver will fund two main research objectives: 1) Defining OSCC-associated metagenomic and metabolomic signatures in treatment-naive OSCC cases and...
This $390,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The key products and services to be delivered through this 5-year project include: Optimizing a high-throughput, single-cell co-culture system to isolate individual...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $164,322 to investigate the evolution of pro-tumoral myeloid cells during the initiation of oral cancer. The research aims to develop a preclinical mouse model to study the transition from oral epithelial dysplasia to head and neck squamous cell carcinoma, with a focus on the immune landscape and suppressive myeloid...
This federal Project Grant award, valued at $229,440.00 and provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the underlying mechanisms contributing to the divergent responses between head and neck squamous cell carcinoma (HNSCC) and pancreatic adenocarcinoma (PDAC) to a combination of radiation therapy, PD1-IL2V immunocytokine, and OX40 agonism. The research aims...
This $469,830 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the use of health-associated oral bacterial species as anti-cancer and immunomodulatory agents for the prevention and treatment of oral squamous cell carcinoma (OSCC). The key research objectives are to: 1) Assess the effect of Streptococcus mitis and Haemophilus parainfluenzae on the...
This $612,048 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the mechanisms by which the lysyl oxidase propeptide (LOX-PP) regulates macrophage phenotype and contributes to oral squamous cell carcinoma (OSCC) tumor suppression. The primary focus is on understanding how a polymorphic variant of LOX-PP loses its ability to block FGFR signaling in...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $642,488 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The 5-year project, running from June 2025 to March 2030, will focus on determining the mechanisms by which the MARCHF8 protein promotes the degradation of major histocompatibility complex class I (MHCI) in human...
The U.S. National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,880,856 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Ohio State University. The 5-year grant, running from September 4, 2024 to May 31, 2029, will support research to determine the mechanistic role of the oral glucocorticoid system in oral cancer development and metastasis, as well as the effects of the chemopreventive agent gallic acid on the glucocorticoid metabolic...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $808,264 to The Medical University of South Carolina to conduct research aimed at elucidating the mechanisms underlying filopodia-mediated intracellular delivery of small interfering RNAs (siRNAs) via a peptide carrier, with the goal of developing a targeted molecular therapy for oral cancer. The key focus of...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $550,296 to support the development of an innovative multimodal imaging-based diagnostic platform to assess the risk of precancerous oral lesions. The key products and services to be delivered include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging to...