This federal Project Grant award, totaling $164,322, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award supports research to investigate the mechanism by which myeloid cells in pre-cancerous oral lesions develop a suppressive phenotype, which inhibits the anti-tumor immune response. The research aims to develop strategies to intercept the evolution of these pro-tumoral myeloid cells,...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will fund research to improve understanding of the role of human papillomavirus (HPV) integration structures in oropharyngeal squamous cell carcinoma (OPSCC) molecular heterogeneity. The $2,942,347 award, effective August 1, 2024 through April 30, 2029, will support the development of a novel targeted capture...
This $1,403,398 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to utilize advanced imaging approaches to develop a set of imaging-based biomarkers for head and neck squamous cell carcinoma (HNSCC) based on the hybrid epithelial/mesenchymal (HEM) state and its interactions with the immune system. The primary objectives are to: 1) further define the effect of HEM on immune...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $2,764,816 to The Trustees of the University of Pennsylvania for a 5-year research project beginning August 1, 2024. The project aims to elucidate the interactions between HPV E6 oncoprotein levels, mitochondrial function, and treatment resistance in HPV-positive oropharyngeal squamous cell carcinomas (OPSCC). The...
This $2,796,216 Project Grant award from the National Institute of Dental and Craniofacial Research (CFDA 93.121 - Oral Diseases and Disorders Research) supports research to determine the mechanisms of action of p53 and p300 reactivation in response to the compound OHM1 for the treatment of human papillomavirus (HPV)-positive oropharyngeal cancer (OPC). The research aims to: 1) Evaluate how OHM1 modulates the p53 post-translational modification code to control p53 functionality and levels, and...
This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
This $170,208 four-year Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research aimed at defining the mechanisms through which polyamines (PAs) modulate anti-tumor immunity in head and neck squamous cell carcinoma (HNSC). The research will utilize quantitative histology, mass spectrometry imaging, in vitro cell culture models, metabolomics, and in vivo HNSC mouse...
This $2,042,210 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research to understand the mechanisms by which HIV infection and chronic inflammation contribute to the development of oropharyngeal cancer (OPC) in people living with HIV (PWH). The key objectives are to: 1) Determine the HPV types present in OPC from PWH and assess impairment of anti-tumor T cell...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $515,812 to The Johns Hopkins University to study the progression of HPV-related oropharynx cancer (HPV-OPC) and how it differs between individuals with and without HIV. The study aims to: 1) characterize the impact of HIV on oral HPV16 persistence, 2) evaluate the performance of oral and blood biomarkers for...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $204,688 to The Johns Hopkins University to research the use of Salmonella-derived nanoparticles for cancer immunotherapy. The key products and services to be delivered include: Evaluating and comparing the ability of Salmonella-derived antigens (SAL-9RE7 and SOMV-9RE7) to induce tumor control and HPV E7-specific...