Project Grant R03DE034506

Award Date 7/15/25
Completion Date 7/14/27
Dollars Obligated $320K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Texas, USA
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This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance understanding of the mechanisms behind radiotherapy resistance in head and neck squamous cell carcinoma (HNSCC). The $320,000 award, effective from July 15, 2025 to July 14, 2027, supports research conducted by Baylor College of Medicine to:

  1. Investigate how the KEAP1/NRF2 signaling pathway and the tumor immune microenvironment (TIME) influence radioresistance in HNSCC tumors, and

  2. Explore whether manipulating the DNA damage response pathway using PARP inhibitors can overcome radioresistance in NRF2-overexpressing HNSCC tumors.

The research leverages a novel genetically engineered mouse model developed by the grantee to study the role of KEAP1 loss and NRF2 overexpression in HNSCC radioresistance. The findings are expected to provide a framework for future R01 grant applications and help improve outcomes for patients with HPV-negative HNSCC.

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