Project Grant R01DE033686
- This federal Project Grant award of $3,742,682 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Dana-Farber Cancer Institute, Inc. (DFCI) in Massachusetts. The grant supports research to dissect the role of the chemokine CCL5 in shaping antigen-specific T cell responses against head and neck cancers. Key objectives include: Investigating how CCL5 chemokine networks impact the development...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $129,289 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Leland Stanford Junior University. The grant funds research to develop lysosome-targeting chimeras (LYTACs) that can degrade immune checkpoint proteins and enhance immunoradiotherapy for head and neck cancer. The project aims to evaluate the impact of LYTACs on immune cell modulation and their therapeutic potential in...
- This $234,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to investigate the combination of radiotherapy (RT) and IAP (inhibitor of apoptosis proteins) antagonism for inducing systemic anti-tumor immune responses in head and neck cancer. The award to Emory University covers the project period from Apr 1, 2025 to Mar 31, 2027. The research aims...
- The Project Grant award titled "DECIPHERING THE MECHANISM OF RESPONSE TO NOVEL HPV-SPECIFIC VIRAL IMMUNE THERAPY IN HPV ASSOCIATED HEAD AND NECK CANCER" was provided by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The $451,000 award supports research conducted by the University of Chicago to develop and evaluate a novel immunotherapy platform called HB-200, which uses attenuated...
- This $642,488 Project Grant was awarded on June 10, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the federal Oral Diseases and Disorders Research program (CFDA 93.121). The grant supports research conducted by a collaborative partnership between Henry Ford Health and Michigan State University Health Sciences to investigate mechanisms by which human papillomavirus (HPV) drives immune evasion in head and neck squamous cell carcinomas (HNSCC). The research aims...
- The Project Grant award titled "UNDERSTANDING THE MECHANISMS BEHIND RADIOTHERAPY RESISTANCE OF IMMUNOLOGICALLY COLD HEAD AND NECK CANCER" was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The $320,000 award will support research conducted by Baylor College of Medicine to develop a novel genetically engineered mouse model (GEMM) to study the role of the KEAP1/NRF2...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $716,123 Project Grant to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Florida. The grant, awarded on September 8, 2025, aims to establish a clinical cohort and develop novel analytical methodologies to validate, discover, and optimize non-invasive liquid biopsy tests for prognosis prediction in head and...
- This Project Grant award of $592,080.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to identify the anti-cancer and immunomodulatory properties of Streptococcus species within the tumor microenvironment of oropharyngeal squamous cell carcinoma (OSCC). The interdisciplinary research team at the University of Puerto Rico Medical Sciences Campus will aim to stimulate anti-tumor...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $204,688 to The Johns Hopkins University to develop Salmonella-derived nanoparticles for cancer immunotherapy. The project aims to generate tumor-specific CD8+ T cell immunity by enhancing the antigen cross-presentation capabilities of dendritic cells, using fusion proteins like albumin-FLT3L and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $427,208 to Virginia Commonwealth University (VCU) to evaluate the immunotherapeutic activity and mechanism of action of a novel immune prime agent, called hFLAGRP170, in enhancing head and neck cancer responsiveness to standard treatments like radiation therapy and immune checkpoint inhibitors. The research aims to investigate how this microbial chimeric molecule can orchestrate innate and adaptive antitumor immunity to address the unmet clinical need for improving outcomes in patients with advanced head and neck cancer. The award began on August 12, 2025 and is scheduled for completion by May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.2k | 8/12/25 |