This federal Project Grant award of $533,675.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research aimed at improving bone regeneration and modulating cellular senescence in radiation-damaged jawbones. The awardee, Trustees of Dartmouth College, will develop a combined 3D-printed mineral scaffold and cryogel construct to enhance bone formation and mitigate the detrimental effects of radiation exposure, which can lead to conditions like osteoradionecrosis. The research project, scheduled to run from July 1, 2025 to March 31, 2030, will involve in vitro studies on senescence modulation as well as in vivo testing in a murine model of radiation-induced osteonecrosis of the mandible. The goal is to create a targeted, cost-effective treatment option that can stimulate bone regeneration and address the cellular-level impacts of radiation therapy, which is a significant clinical problem for head and neck cancer patients.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $533.7k | 6/25/25 |