The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $466,500 Project Grant under the Oral Diseases and Disorders Research Program (CFDA 93.121) to the University of Colorado-Denver. The grant aims to develop near-infrared chemiluminescent and fluorescent nanoparticles that can be activated by body heat and stored at low temperatures to improve the detection of micrometastatic cancer and guide image-guided surgery. The 3-year project will leverage in vivo and ex vivo...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,465,026 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The University of Texas MD Anderson Cancer Center. The grant funds the "HARVARD MD ANDERSON COLLABORATIVE TO REDUCE LYMPHATIC MORBIDITY IN HEAD AND NECK CANCER WITH ARTIFICIAL INTELLIGENCE (HARMONIC-AI)" project. The project aims to leverage computational imaging and artificial intelligence to: 1) tailor...
This $164,322 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The grant supports research to investigate the evolution of pro-tumoral myeloid cells during the transition from oral epithelial dysplasia to head and neck squamous cell carcinoma. The study aims to develop a high-resolution atlas of myeloid cell subsets in precancerous lesions and identify potential...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development and commercialization of a targeted fluorescence dye for intraoperative imaging and precision surgical treatment of head and neck cancer (HNC). The $294,505 award aims to synthesize and characterize a small peptide-based fluorescence probe that can specifically target an oncoprotein in the extracellular...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $889,616 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Regents of the University of Minnesota. The grant, with a project period from September 16, 2024 to August 31, 2026, will support research to investigate the localization of specific migratory RNAs within neural crest cell protrusions and their role in directed cell migration. The research aims to provide insights into the...
The federal Project Grant award R01DE033741, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to define the relationship between the hybrid epithelial/mesenchymal (HEM) state in head and neck squamous cell carcinoma (HNSCC) and its impact on immune infiltration. The $701,699 award to The General Hospital Corporation (Massachusetts General Hospital) will utilize advanced...
This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop an innovative multimodal imaging diagnostic platform for risk assessment of precancerous oral lesions. The $550,296 award, with a project period from September 2024 to September 2025, will integrate Fourier transform infrared (FTIR) imaging, histological imaging, and spatial transcriptomics techniques,...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $148,569 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Regents of the University of Michigan to conduct a multiparametric characterization of periodontal tissues for improved inflammation monitoring. The research project aims to establish quantitative ultrasound biomarkers and a machine learning classifier to better characterize the inflammatory condition of periodontal tissues. Key...
This $234,000 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The grant will fund a study to investigate the functional roles and mechanisms of the human microbiome in oral squamous cell carcinoma (OSCC), a prevalent and lethal form of head and neck cancer. The research aims to define OSCC-associated metagenomic and metabolomic signatures, as well as determine...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $619,347 to Light Research Inc. to develop a compact multimodal intraoral camera. The device integrates polarized white light imaging, autofluorescence imaging, optical coherence tomography, and near-infrared transillumination imaging modalities to improve the detection and diagnosis of dental caries...