This $695,814 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program supports research and development of artificial intelligence (AI) technologies to enable online adaptive proton therapy for head and neck cancer treatment. The project aims to apply AI to key components of the adaptive radiation therapy workflow, including 3D CT image...
This federal Project Grant award for $234,750.00, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to enhance radiation therapy's ability to stimulate systemic anti-tumor immune responses. The research will be conducted by Emory University and will focus on two key objectives: Using innovative, orthotopic abscopal murine models of oral cancer to determine if the IAP antagonist...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Program (CFDA 93.121), provides $1,465,026 to The University of Texas MD Anderson Cancer Center to develop AI-powered tools for early detection and risk assessment of lymphedema and fibrosis in head and neck cancer patients. The primary objectives are to: Use AI to analyze pre-treatment CT scans and tailor treatment plans to minimize post-treatment...
This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of CRANIAMAP - an integrated software suite for auto-segmentation and landmarking of cone beam computed tomography (CBCT) scans. The $306,633 award to Ther-Ai LLC will fund the initial Phase I development of CRANIAMAP, which aims to significantly enhance the accuracy and efficiency of CBCT...
This $606,296 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support the development of advanced three-dimensional (3D) craniofacial growth models at the University of Missouri System. The project aims to create new growth standards that incorporate the latest cone-beam computed tomography (CBCT) imaging technology, enabling more accurate assessment and prediction of...
This $350,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports the development of Deep Reasoning AI's "DR-AIVATAR" platform. The DR-AIVATAR is a multi-agent AI system for personalized 3D anatomical modeling, surgical planning, and decision-making, with an initial focus on craniomaxillofacial reconstructions and oncologic resections. Key objectives...
This federal Project Grant award for $353,763, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the mechanisms underlying poor response to epidermal growth factor receptor (EGFR) inhibitors in head and neck squamous cell carcinoma (HNSCC) treatment when combined with radiotherapy. The key objectives are to determine if interleukin-1 (IL-1)-mediated NADPH oxidase...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $499,105 to The University of Iowa to develop miRNA-based therapeutics to enhance bone regeneration and suppress bone resorption in oral cancer patients receiving radiation therapy. The key objectives are to determine the functions of miR-200c in promoting mandibular bone regeneration under radiation and preventing bone...
This federal Project Grant award of $1,297,941 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to develop a novel, cutting-edge dental restoration platform. The key products and services to be delivered include: A self-improving dental adhesive (Auto-Enhancing Universal Dental Adhesive or AUDA) that enhances its bond with the tooth by facilitating mineralization at the interface. This will be...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund the development of a novel ultrasound-based molecular imaging tool to detect small metastatic deposits in the lymph nodes of head and neck cancer patients. The $1,352,406.84 award, with a performance period from Sep 2024 to Jun 2028, will support the creation of targeted perfluorocarbon nanodroplet contrast agents and...