Project Grant R16DE035974
- This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
- This Project Grant award of $315,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The goal of this 2-year project is to study the role of the TRPC1 protein as a potential therapeutic target for treating oral squamous cell carcinoma (OSCC), a common and deadly type of head and neck cancer. The research will focus on understanding how TRPC1 mediates calcium...
- This federal Project Grant award of $483,360.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to target vulnerabilities in the EGFR/HER3/HER2 oncogenic signaling circuitry for developing new precision therapies for oral cancer. The project aims to explore synthetic lethal and gene interaction networks to expose druggable systems vulnerabilities and uncover mechanisms of...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $390,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical College of Wisconsin, Inc. The grant funds a 5-year research project to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The project aims to develop innovative methods to isolate and characterize tumor-infiltrating...
- This federal Project Grant award of $1,899,042.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research at the University of Pittsburgh to analyze high-dimensional genomic datasets to reveal mechanistic insights on divergent outcomes of head and neck cancer. The project aims to use existing public databases of human head and neck squamous cell carcinomas (HNSCC) to identify new mechanisms...
- This $612,048 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to investigate the role of the lysyl oxidase propeptide (LOX-PP) in regulating macrophage phenotypes and their impact on oral squamous cell carcinoma (OSCC) tumor suppression. The research aims to characterize the differential effects of wildtype versus variant LOX-PP on macrophage activation,...
- This federal Project Grant award of $3,742,682 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Dana-Farber Cancer Institute, Inc. (DFCI) in Massachusetts. The grant supports research to dissect the role of the chemokine CCL5 in shaping antigen-specific T cell responses against head and neck cancers. Key objectives include: Investigating how CCL5 chemokine networks impact the development...
- This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
- The Project Grant award of $205,000.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the relationship between the oral microbiome and adverse outcomes in pediatric hematopoietic cell transplant recipients. The key products and services to be delivered under this award include: Collecting oral samples (supragingival plaque and saliva) and blood samples...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $427,208 to Virginia Commonwealth University (VCU) to evaluate the immunotherapeutic activity and mechanism of action of a novel immune prime agent, called hFLAGRP170, in enhancing head and neck cancer responsiveness to standard treatments like radiation therapy and immune checkpoint inhibitors. The research aims to...
This Project Grant award of $592,080.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to identify the anti-cancer and immunomodulatory properties of Streptococcus species within the tumor microenvironment of oropharyngeal squamous cell carcinoma (OSCC). The interdisciplinary research team at the University of Puerto Rico Medical Sciences Campus will aim to stimulate anti-tumor immune responses and/or modulate the microbiota to promote OSCC tumor regression. The project will also involve training the next generation of scientists in cancer immunology. This award supports research activities from August 1, 2025 through July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $592.1k | 7/24/25 |