This Project Grant award of $1,839,472 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to define dysbiosis and identify microbial changes that are predictive of periodontitis progression and stability. The project aims to utilize the biobank and longitudinal data from the previous "Biomarkers of Periodontal Disease Progression (BPDP)" study to examine microbial, immunological, and metabolomic signatures associated with periodontitis progression versus stability. The research team, which includes experts in microbiology, immunology, and computational biology, will apply advanced multi-omics integration and predictive modeling approaches to gain mechanistic insights into the bacterial and host changes leading to dysbiosis and periodontal destruction. This research is expected to provide critical insights to inform strategies for the prevention and treatment of periodontitis. A sub-award of this grant was made to the Children's Hospital of Philadelphia (CHOP) Research Institute, which will contribute its specialized expertise in pediatric medical research and healthcare innovation to the project.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $559.3k | 3/20/25 | ||
| Not listed | $640.1k | 5/17/24 | ||
| Not listed | $640.1k | 5/17/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
500213S | The Children's Hospital Of Philadelphia | Project Grant R01DE033033 | $228.8k | 8/23/24 |