This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research by The Forsyth Institute to investigate microbe-microbe interactions within the oral microbiome. The $162,216 grant, awarded on June 10, 2024, will enable the institute to employ a combination of expansion microscopy and multiplex FISH imaging to analyze microbial adhesion and organization at the single-cell level. The research aims to quantify relative microbe-microbe adhesion forces within biofilms, both in vitro and in natural human oral biofilms. This work will enhance understanding of the functional attributes and complex dynamics of the oral microbiome and its implications for human health. The Forsyth Institute, a prominent non-profit research organization, has a long history of pioneering oral health research and frequently collaborates on federally-funded projects.
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